ArticleScientific reports2022
Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Strengthening trauma care in low- and middle-income countries through guideline adaptation and scalable system reforms.World journal of methodology · 2026Review
- Recent Advances in Prehospital and In-Hospital Management of Patients with Severe Trauma.Journal of clinical medicine · 2025Review
- Bridging the gap: whole blood and plasma in prehospital hemorrhagic shock resuscitation.Trauma surgery & acute care open · 2025Review
- Impact of Pre-Hospital Intravenous Infusion on Physiological Parameters in Severe Trauma Patients.Cureus · 2024Article
- Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock.Apoptosis : an international journal on programmed cell death · 2024Article
- The volume of infusion fluids correlates with treatment outcomes in critically ill trauma patients.Frontiers in medicine · 2022Article
- Clinical Impact of Initial Fluid Resuscitation in Patients With Cardiogenic Shock.Acute medicine & surgeryArticle
- Development of a national out-of-hospital transfusion protocol: a modified RAND Delphi study.CMAJ openArticle
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Authors and funding
13 authors at 20 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prehospital fluid resuscitation with crystalloids in patients following trauma remain controversial. This study aimed to investigate the association between prehospital fluid resuscitation and outcomes of trauma patients in Asia. We conducted a retrospective cohort study of trauma patients between 2016 and 2018 using data from the Pan-Asia Trauma Outcomes Study (PATOS) database. Prehospital fluid resuscitation was defined as any administration of intravenous crystalloid fluid on the ambulance before arrival to hospitals. The outcomes were in-hospital mortality and poor functional outcomes, defined as Modified Rankin Scale ≥ 4. Propensity score matching (PSM) was used to equalize potential prognostic factors in both groups. This study included 31,735 patients from six countries in Asia, and 4318 (13.6%) patients had ever received prehospital fluid resuscitation. The patients receiving prehospital fluid resuscitation had a higher risk of in-hospital mortality, with an adjusted odds ratio (aOR) of 2.02, 95% confidence interval (CI) 1.32-3.10, p = 0.001 in PSM analysis. Prehospital fluid resuscitation was also associated with poor functional outcomes, with an OR 1.73, 95% CI: 1.48-2.03, p < 0.001 in PSM analysis. Prehospital fluid resuscitation in patients with major trauma (injury severity score ≥ 16) presented a higher risk of poor functional outcomes (aOR = 2.65, 95% CI: 1.89-3.73 in PSM analysis, p
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