Evidence map›Paper›PMID 35260294›Full record

ReviewSeminars in cell & developmental biology2023

The transcriptional portraits of the neural crest at the individual cell level.

Alek G Erickson, Polina Kameneva, Igor Adameyko

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  16. Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Piezo1 and Piezo2 collectively regulate jawbone development.Development (Cambridge, England) · 2024
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alek G EricksonDepartment of Physiology and Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.
Polina KamenevaDepartment of Neuroimmunology, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
Igor AdameykoDepartment of Physiology and Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden; Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria. Electronic address: igor.adameyko@ki.se.

Funding

Signaling mechanisms underlying neural crest cell fate decisionsF32DE029662 · NIDCR · KAROLINSKA INSTITUTE · PI ERICKSON, ALEK G · 2021 to 2023
$219k
NIDCR NIH HHS F32 DE029662
6 · The paper itself

Abstract

Since the discovery of this cell population by His in 1850, the neural crest has been under intense study for its important role during vertebrate development. Much has been learned about the function and regulation of neural crest cell differentiation, and as a result, the neural crest has become a key model system for stem cell biology in general. The experiments performed in embryology, genetics, and cell biology in the last 150 years in the neural crest field has given rise to several big questions that have been debated intensely for many years: "How does positional information impact developmental potential? Are neural crest cells individually multipotent or a mixed population of committed progenitors? What are the key factors that regulate the acquisition of stem cell identity, and how does a stem cell decide to differentiate towards one cell fate versus another?" Recently, a marriage between single cell multi-omics, statistical modeling, and developmental biology has shed a substantial amount of light on these questions, and has paved a clear path for future researchers in the field.

Indexed as

Neural CrestStem CellsAnimalsCell DifferentiationVertebratesComputational biologyFate decisionsFate determinationMicro-heterogeneityMultipotencyNeural crestSingle cell transcriptomics

Identifiers

PMID35260294
PMCPMC9441473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.