ArticleReproductive biology and endocrinology : RB&E2022
Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro fertilization/intracytoplasmic sperm injection outcomes: a retrospective cohort study.
Article in Reproductive biology and endocrinology : RB&E, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Impact of SARS-CoV-2 infection on clinical outcomes ofFrontiers in endocrinology · 2023Pooled it
- Semen parameters and sex hormones as affected by SARS-CoV-2 infection: A systematic review.Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie · 2022Pooled it
- Divergent long-term trends in semen quality and reproductive hormones across the COVID-19 pandemic era in infertile men: an age-stratified retrospective study.Basic and clinical andrology · 2026Article
- Pregnancy and obstetric outcomes of frozen-thawed embryo transfer with embryos generated from COVID‑19 infection during controlled ovarian stimulation: a retrospective study.Journal of assisted reproduction and genetics · 2025Article
- Article
- Impact of Coronavirus Disease 2019 on Fertility: An Integrative Review.The International journal of health planning and management · 2025Review
- Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Impact of COVID-19 infection on laboratory and clinical outcomes of ovarian stimulation using antagonist protocol.Frontiers in medicine · 2025Article
- Outcomes of female reproductive performance with assisted reproductive techniques after recent mild to moderate COVID-19 infections: An observational study.Clinical and experimental reproductive medicine · 2024Article
- Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection.Scientific reports · 2024Article
- COVID-19 and persistent symptoms: implications for polycystic ovary syndrome and its management.Frontiers in endocrinology · 2024Review
- The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment.Frontiers in endocrinology · 2024Article
- The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study.Science China. Life sciences · 2023Article
- Effect of prior female SARS-CoV-2 infection on IVF outcomes: a prospective cohort study.Frontiers in endocrinology · 2023Article
- Impact of COVID-19 convalescence on pregnancy outcomes in patients undergoing IVF/ICSI during fresh ART cycles: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- The bibliometric analysis of studies on intracytoplasmic sperm injection from 2002 to 2021.Frontiers in endocrinology · 2023Article
- Novel compound heterozygous mutations inAsian journal of andrology · 2023Article
- COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics.Life (Basel, Switzerland) · 2022Article
- Mild COVID-19 Was Not Associated with Impaired IVF Outcomes or Early Pregnancy Loss in IVF Patients.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the influences of SARS-CoV-2 infection on semen parameters and investigate the impact of the infection on in vitro fertilization (IVF) outcomes.
methodsThis retrospective study enrolled couples undergoing IVF cycles between May 2020 and February 2021 at Tongji Hospital, Wuhan. Baseline characteristics were matched using propensity score matching. Participants were categorized into an unexposed group (SARS-COV-2 negative) and exposed group (SARS-COV-2 positive) based on a history of SARS-CoV-2 infection, and the populations were 148 and 50 after matching, respectively. IVF data were compared between the matched cohorts. Moreover, semen parameters were compared before and after infection among the infected males. The main measures were semen parameters and IVF outcomes, including laboratory and clinical outcomes.
resultsGenerally, the concentration and motility of sperm did not significantly differ before and after infection. Infected males seemed to have fewer sperm with normal morphology, while all values were above the limits. Notably, the blastocyst formation rate and available blastocyst rate in the exposed group were lower than those in the control group, despite similar mature oocytes rates, normal fertilization rates, cleavage rates, and high-quality embryo rates. Moreover, no significant differences were exhibited between the matched cohorts regarding the implantation rate, biochemical pregnancy rate, clinical pregnancy rate, or early miscarriage rate.
conclusionsThe results of this retrospective cohort study suggested that the semen quality and the chance of pregnancy in terms of IVF outcomes were comparable between the males with a history of SARS-CoV-2 infection and controls, although a decreased blastocyst formation rate and available blastocyst rate was observed in the exposed group, which needs to be reinforced by a multicenter long-term investigation with a larger sample size.
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