ArticleBMC musculoskeletal disorders2022
Ligamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Graded ankle instability induces early osteoarthritic changes in a rat model.Osteoarthritis and cartilage open · 2026Article
- Investigation of acute and chronic injury mechanisms of the deltoid ligament: insights from finite element analysis and animal study.Journal of orthopaedic surgery and research · 2026Article
- Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling.Scientific reports · 2026Article
- A LASSO regression-driven nomogram to predict functional outcomes after surgery for chronic lateral ankle instability.Frontiers in surgery · 2026Article
- A head-to-head comparison of high-frequency ultrasound and magnetic resonance imaging for preoperative assessment of ATFL tears and concomitant CFL injuries.Frontiers in surgery · 2026Article
- No Difference in Ligament Discontinuity Versus Thickening on Magnetic Resonance Imaging When Evaluating Anterior Talofibular Ligament Injuries: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2025Review
- Talus Position Correlates With Dorsiflexion Range of Motion Following a Lateral Ankle Sprain: A Cross-Sectional Study.Health science reports · 2025Article
- Article
- Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis.Arthritis research & therapy · 2024Article
- Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.Science advances · 2024Article
- Progress in diagnosis and treatment of acute injury to the anterior talofibular ligament.World journal of clinical cases · 2023Review
- Mouse model of subtalar post-traumatic osteoarthritis caused by subtalar joint instability.Journal of orthopaedic surgery and research · 2022Article
- A new mouse model of ankle instability induced by multiple mechanical sprains with controlled inversion angle and speed.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to explore the relationship between surgically-induced ankle instability and posttraumatic osteoarthritis (PTOA) in a mouse model, and to provide reference for clinical practice.
resultsLigamentectomy was performed on 24 eight-week-old male C57BL/6 J mice, which were divided into three groups. Both the anterior talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) were severed in the CFL + ATFL group, while only the CFL was removed in the CFL group. The SHAM group was set as the blank control group. A wheel-running device was used to accelerate the development of ankle osteoarthritis (OA). Balance measurement, footprint analysis, and histological analysis were used to assess the degree of ankle instability and OA. According to the balance test results, the CFL + ATFL group demonstrated the highest number of slips and the longest crossing beam time at 8 weeks postoperatively. The results of gait analysis exhibited that the CFL + ATFL group had the most significant asymmetry in stride length, stance length, and foot base width compared to the CFL and SHAM groups. The OARSI score of the CFL + ATFL group (16.7 ± 2.18) was also much higher than those of the CFL group (5.1 ± 0.96) and the SHAM group (1.6 ± 1.14).
conclusionBased on the mouse model, the findings indicate that severe ankle instability has nearly three times the chance to develop into ankle OA compared to moderate ankle instability.
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