ArticleBMC psychiatry2022
Transdiagnostic alterations in neural emotion regulation circuits - neural substrates of cognitive reappraisal in patients with depression and post-traumatic stress disorder.
Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Emotion regulation and mental health across cultures: a systematic review and meta-analysis.Nature human behaviour · 2025Pooled it
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory.Translational psychiatry · 2026Trial
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Changes in neural responses during affective and non-affective tasks and improvement of posttraumatic stress disorder symptoms following trauma-focused psychotherapy.Translational psychiatry · 2023Trial
- Network-level structural alterations distinguish persistent from remitted post-traumatic stress disorder: a morphometric covariance approach.European journal of psychotraumatology · 2026Article
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Neurological Responses to Scented Insects via Olfactory Stimulation: A Controlled fMRI Study.Insects · 2026Article
- Symptom severity, neighborhood crime, and neural correlates of reappraisal in patients with major depression and social anxiety.Psychological medicine · 2026Article
- Autonomic regulation during cognitive reappraisal in major depressive disorder: a study of fMRI correlates.BMC psychiatry · 2025Article
- Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS.Journal of autism and developmental disorders · 2025Observational
- Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex.iScience · 2025Article
- Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Substance Use Disorder (SUD)-A Review and Insights into Possible Mechanisms of Action.Journal of clinical medicine · 2025Review
- Advances in Neuroimaging and Deep Learning for Emotion Detection: A Systematic Review of Cognitive Neuroscience and Algorithmic Innovations.Diagnostics (Basel, Switzerland) · 2025Review
- Emotional regulation mechanisms regarding posttraumatic and depressive symptoms in maltreated youth.Frontiers in public health · 2025Article
- Neural correlates and plasticity of explicit emotion regulation following the experience of trauma.Frontiers in behavioral neuroscience · 2025Review
- An objective quantitative diagnosis of depression using a local-to-global multimodal fusion graph neural network.Patterns (New York, N.Y.) · 2024Article
- Does Trauma Change the Way Individuals with Post-Traumatic Stress Disorder (PTSD) Deal with Positive Stimuli?Behavioral sciences (Basel, Switzerland) · 2024Article
- Review
- Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity.Psychoradiology · 2024Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired cognitive reappraisal, associated with the social functioning and well-being of patients affected by mood or anxiety disorders, is characterized by distinct neural activation patterns across clinical populations. To date, studies dedicated to identifying common and distinct neural activation profiles need to be clarified. The aim of the present study was to investigate transdiagnostic differences and commonalities in brain activation patterns during reappraisal-mediated downregulation of emotions.
methodsCognitive reappraisal of negative images was contrasted with maintaining emotions during a control viewing condition. Brain activation in 35 patients with major depressive disorder (MDD), 20 patients with post-traumatic stress disorder (PTSD), and 34 healthy controls (HC) during cognitive reappraisal was compared. Moreover, the neural circuitry of emotion regulation in these clinical populations was examined using seed-to-voxel and voxel-to-voxel functional connectivity analyses.
resultsWhole-brain fMRI analyses showed less right-lateralized activation of the inferior, middle, and superior frontal gyrus during cognitive reappraisal compared to viewing of negative images in MDD and PTSD patients compared to HCs. Right IFG activation was negatively correlated with the severity of anxiety and depressive symptomatology. In addition, increased seed-to-voxel connectivity of the right IFG as well as increased voxel-to-voxel connectivity was observed in PTSD patients compared to HCs and MDD patients.
conclusionsFMRI results therefore suggested a common deficit of depression and anxiety symptomatology reflected by reduced activation in right IFG during cognitive reappraisal as well as diagnosis specific effects in patients with PTSD based on seed-to-voxel and voxel-to-voxel connectivity showing an overactive and hyperconnected salience network. Findings highlight the role of transdiagnostic research to identify disorder specific brain patterns as well as patterns common across disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.