ArticleBMC musculoskeletal disorders2022
The temporal relation between pain and fatigue in individuals receiving treatment for chronic musculoskeletal pain.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.Acta neurologica Belgica · 2025Pooled it
- Resting state brain connectivity of pain and fatigue is affected by performance of a fatiguing attention task in patients with chronic pain.Neuroimage. Reports · 2026Article
- Structural equation modeling to explore putative causal factors for chronic fatigue in childhood cancer survivors: a DCCSS LATER study.Journal of cancer survivorship : research and practice · 2026Article
- [Pain and fatigue therapy in children and adolescents (SHARK): care model and initial evaluation results].Schmerz (Berlin, Germany) · 2026Article
- Risk Factors for Fatigue in Adults Receiving Maintenance Hemodialysis Who Have Chronic Pain: A Secondary Analysis of the HOPE Consortium Trial.Kidney medicine · 2026Article
- The Handgrip Endurance Task as a Simple Clinical Indicator of Mental Fatigue in Patients with Chronic Low Back Pain.Journal of pain research · 2026Article
- The relationship between body pain, physical fatigue, and mental fatigue in Chinese adolescents.Frontiers in public health · 2026Article
- Exploring patient experiences of pain fatigue and physical activity in syndromic heritable thoracic aortic disease using mixed methods.Scientific reports · 2025Article
- Utilization of CoRDS registry to monitor quality of life in patients with VCP multisystem proteinopathy.Orphanet journal of rare diseases · 2025Article
- Addressing treatment fatigue, therapeutic inertia, and cognitive dissonance in musculoskeletal pain management in primary care setting.Frontiers in medicine · 2025Article
- Description of pain associated with persistent postoperative pain after total knee arthroplasty.Scientific reports · 2024Article
- Nordic Walking as a Non-Pharmacological Intervention for Chronic Pain and Fatigue: Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous investigations have revealed significant relations between pain and fatigue in individuals with persistent pain conditions. However, the direction of influence between pain and fatigue remains unclear. Shortcomings of design and analytic approaches used in previous research limit the nature of conclusions that can be drawn about possible causal or directional relations between pain and fatigue. The present study investigated the temporal relation between changes in pain and changes in fatigue in individuals with musculoskeletal pain enrolled in a 10-week behavioral activation intervention. On the basis of previous findings, it was hypothesized that analyses would support a bi-directional relation between pain and fatigue.
methodsThe study sample consisted of 104 individuals with chronic musculoskeletal pain participating in a 10-week standardized rehabilitation intervention. Measures of pain intensity and fatigue were completed pre-, mid-, and post-treatment. The three-wave data panel permitted examination of the direction of influence between pain and fatigue through the course of the intervention. A random-intercept cross-lagged panel model (RI-CLPM) was used to examine the temporal relation between pain and fatigue.
resultsConsistent with previous research, cross-sectional analyses of pre-treatment data revealed significant correlations between measures of pain and fatigue. Significant reductions in pain and fatigue were observed through the course of treatment (d = 0.33 and d = 0.66, p < .001, respectively). RI-CLPM revealed that pain severity predicted later fatigue (pre to mid-treatment standardized path coefficient (β) = 0.55, p = 0.02; mid to post-treatment β = 0.36, p = 0.001); however, fatigue did not predict later pain severity.
conclusionsDiscussion addresses the processes that might underlie the temporal relation between pain and fatigue. Clinical implications of the findings are also discussed.
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