ArticleChronobiology international2022
Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults: an analysis from NHANES 2011-2014.
Article in Chronobiology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Long-term night shift work and cardiometabolic health in healthcare workers: a review of mechanisms and precision intervention strategies.Frontiers in public health · 2026Pooled it
- Time matters: circadian genetics and the molecular logic of human health and disease.Nature reviews. Genetics · 2026Review
- Associations of sedentary behavior and physical activity with sleep disorders in patients with osteoarthritis: The mediating role of inflammatory biomarkers.Osteoarthritis and cartilage open · 2026Article
- Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Rest-activity rhythms and cardiovascular events in cardiovascular-kidney-metabolic syndrome: evidence from two nationwide cohorts.American journal of preventive cardiology · 2026Article
- Observational
- Article
- Rest Activity Rhythms and Their Association with Cardiorespiratory Fitness and Walking Energetics in Older Adults: Study of Muscle, Mobility, and Aging.Medicine and science in sports and exercise · 2025Article
- Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.Circulation research · 2025Review
- The diverse roles of the circadian clock in cancer.Nature cancer · 2025Review
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Cross-sectional relationships of circadian misalignment and rest-activity rhythms with occupational attainment in UK Biobank participants.Chronobiology international · 2025Article
- Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study.BMC public health · 2024Article
- Circulating white blood cell traits and prolonged night shifts: a cross-sectional study based on nurses in Guangxi.Scientific reports · 2024Article
- Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association between rest-activity rhythm and diabetic retinopathy among US middle-age and older diabetic adults.Frontiers in endocrinology · 2024Article
- Day-to-day deviations in sleep parameters and biological aging: Findings from the NHANES 2011-2014.Sleep health · 2023Article
- Age is Associated with Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility and Aging (SOMMA).medRxiv : the preprint server for health sciences · 2023Article
- Article
- Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants.Nature communications · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythm disruption is associated with immune system disturbance and has been observed in many health problems where chronic-inflammation acts as a major contributor. We aim to examine whether rest-activity circadian rhythm is associated with chronic inflammation using white blood-cell-based inflammatory indices including white blood cell (WBC) count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII). We analyzed the data from 8089 adults (age≥20) with at least 4 days of validated accelerometer recordings and a valid WBC count from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Non-parametric rest-activity circadian rhythm parameters were derived from the accelerometer recordings. In the models adjusting multiple covariates, a one-quantile increase in relative amplitude (i.e. more robust circadian rhythm) was associated with 1 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.