Evidence map›Paper›PMID 35259981›Full record

ArticleProceedings. Biological sciences2022

Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes.

Daniel S Joyce, Manuel Spitschan, Jamie M Zeitzer

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01119365 naunknown statusnot on this map

Bright Light as a Countermeasure for Circadian Desynchrony

TypeinterventionalSponsorVA Palo Alto Health Care SystemRan2011 to 2023Enrolled300ConditionsHealthyArmsBright light
NCT01406691 phase4recruitingnot on this map

Treating Sleep Disruption in Teens With Millisecond Light Exposure During Sleep

TypeinterventionalSponsorStanford UniversityRan2013 to 2028Enrolled20ConditionsDelayed Sleep Phase DisorderArmsFlashes
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. A millisecond parameter space for phase-shifting the circadian pacemaker with near-ultraviolet light.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025
    Article
  4. Review
  5. Human-Centric Lighting Research and Policy in the Melanopsin Age.Policy insights from the behavioral and brain sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Daniel S JoyceDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6407-4653
Manuel SpitschanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8572-9268
Jamie M ZeitzerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6174-5282
Max Planck Institute for Biological Cybernetics · DEUniversity of Nevada, Reno · USVA Palo Alto Health Care System · US

Funding

Wellcome Trust 204686/Z/16/Z
6 · The paper itself

Abstract

The melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are characterized by a delayed off-time following the cessation of light stimulation. Here, we exploited this unusual physiologic property to characterize the exquisite sensitivity of the human circadian system to flashed light. In a 34 h in-laboratory between-subjects design, we examined phase shifting in response to variable-intensity (3-9500 photopic lux) flashes at fixed duration (2 ms;

Indexed as

MelatoninCircadian RhythmHumansRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRod OpsinsSleepinessWakefulnessMelatoninRod Opsinsalertnesscircadianflashlightmelatoninsleep

Identifiers

PMID35259981
PMCPMC8905166
OpenAlexW4220737325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.