Observational studyEuropean journal of cancer (Oxford, England : 1990)2022
Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID).
Observational study in European journal of cancer (Oxford, England : 1990), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04406571 (Reorganization of the Healthcare System During COVID-19 Pandemic), which is not on this map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reorganization of the Healthcare System During COVID-19 Pandemic: Impact on Management of Patients With Exocrine Pancreatic Cancer
Who cites it
14 citing papers in PubMed.
- Review
- Impact of the COVID-19 Pandemic on Gut Cancer Admissions and Management: A Comparative Study of Two Pandemic Years to a Similar Pre-Pandemic Period.Healthcare (Basel, Switzerland) · 2025Article
- COVID-19 lockdown-related treatment modifications did not impact the outcome of digestive cancers: the Clin-COVIDICA prospective study.BMC cancer · 2025Observational
- Molecular analysis in pancreatic adenocarcinoma: a real-world study from high-volume French centres (CAPANCOBIO study).ESMO gastrointestinal oncology · 2025Article
- The global, regional burden of pancreatic cancer and its attributable risk factors from 1990 to 2021.BMC cancer · 2025Article
- Changes in Pancreatic Cancer Management and Surgical Treatment During the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2024Article
- A comprehensive summary of the impact of the COVID era on various gastrointestinal cancers.Annals of gastroenterological surgery · 2024Article
- Impact of Coronavirus Disease 2019 on the Diagnosis and Treatment of Pancreatic Cancer: An Observational Cohort Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Observational
- Impact of Coronavirus Disease 2019 on Gastric Cancer Diagnosis and Stage: A Single-Institute Study in South Korea.Journal of gastric cancer · 2023Article
- Maintaining early diagnosis of pancreatic adenocarcinoma in Japan: Local resilience against COVID-19.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023Article
- Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.The lancet. Diabetes & endocrinology · 2023Article
- Evaluating the impact of COVID-19 on cancer declarations in Quebec, Canada.Cancer medicine · 2023Article
- The Pancreas in Coronavirus Disease 2019 Infection.Gastroenterology clinics of North America · 2023Review
- Elective surgeries during and after the COVID-19 pandemic: Case burden and physician shortage concerns.Annals of medicine and surgery (2012) · 2022Review
Corrections and comments
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Authors and funding
29 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe COVID-19 pandemic caused major oncology care pathway disruption. The CAPANCOVID study aimed to evaluate the impact on pancreatic adenocarcinoma (PA) - from diagnosis to treatment - of the reorganisation of the health care system during the first lockdown.
methodsThis multicentre ambispective observational study included 833 patients diagnosed with PA between September 1, 2019 and October 31, 2020 from 13 French centres. Data were compared over three periods defined as before the outbreak of COVID-19, during the first lockdown (March 1 to May 11, 2020) and after lockdown.
resultsDuring the lockdown, mean weekly number of new cases decreased compared with that of pre-pandemic levels (13.2 vs. 10.8, -18.2%; p = 0.63) without rebound in the post-lockdown period (13.2 vs. 12.9, -1.7%; p = 0.97). The number of borderline tumours increased (13.6%-21.7%), whereas the rate of metastatic diseases rate dropped (47.1%-40.3%) (p = 0.046). Time-to-diagnosis and -treatment were not different over periods. Waiting neoadjuvant chemotherapy in resectable tumours was significantly favoured (24.7%-32.6%) compared with upfront surgery (13%-7.8%) (p = 0.013). The use of mFOLFIRINOX preoperative chemotherapy regimen decreased (84.9%-69%; p = 0.044). After lockdown, the number of borderline tumours decreased (21.7%-9.6%) and advanced diseases increased (59.7%-69.8%) (p = 0.046). SARS-CoV-2 infected 39 patients (4.7%) causing 5 deaths (12.8%).
conclusionThis cohort study suggests the existence of missing diagnoses and of a shift in disease stage at diagnosis from resectable to advanced diseases with related therapeutic modifications whose prognostic consequences will be known after the planned follow-up.
trial registrationClinicaltrials.gov NCT04406571.
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