ArticleBiosensors & bioelectronics2022
Nano gold-doped molecularly imprinted electrochemical sensor for rapid and ultrasensitive cortisol detection.
Article in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 131 citations in OpenAlex.
- Deep eutectic solvent-assisted electropolymerization of MXene-based dual-monomer surface molecularly imprinted sensor for selective detection of myricetin.Analytical and bioanalytical chemistry · 2026Article
- A novel multi-aptamer electrospun nanofibrous membrane for simultaneous selective extraction of monoamine neurotransmitters and determination in biological samples by LC-MS.Analytical and bioanalytical chemistry · 2026Article
- Molecularly Imprinted Polymers for Steroid Hormone Analysis: Design Strategies, Recognition Mechanisms, and Detection Applications.Journal of separation science · 2026Review
- Covalent and non-covalent synergy in molecularly imprinted polymer-coated hollow nanocages for selective electrochemical recognition of azithromycin.Mikrochimica acta · 2026Article
- A high-performance voltammetric sensor based on Co/Ni-metal-organic framework modified electrode for the determination of dopamine in the presence of tyrosine.ADMET & DMPK · 2026Article
- Challenges and opportunities of wearable molecular sensors in endocrinology and metabolism.Nature reviews. Endocrinology · 2026Review
- Electrochemical detection of cortisol in sweat for sports performance analysis using graphene oxide-silicon carbide nanocomposites.Mikrochimica acta · 2025Article
- Advances in molecularly imprinted polymers for clinical biomarker detection (2021-2025).Mikrochimica acta · 2025Review
- Development of Molecularly Imprinted Conducting Polymers for Stress Biomarker Cortisol Detection.ACS applied polymer materials · 2025Article
- Recent Advances on Rapid Detection Methods of Steroid Hormones in Animal Origin Foods.Biosensors · 2025Review
- Innovative Molecular Imprinting Sensor for Quick, Non-Invasive Cortisol Monitoring in Fish Welfare.Biosensors · 2025Article
- A Wearable Molecularly Imprinted Electrochemical Sensor for Cortisol Stable Monitoring in Sweat.Biosensors · 2025Article
- Article
- Electrochemical sensor based on multi-walled carbon nanotubes and two-dimensional zeolitic imidazolate framework nanosheets: Application in determining dacarbazine.ADMET & DMPK · 2025Article
- Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers.Biomicrofluidics · 2024Review
- Signal transduction interfaces for field-effect transistor-based biosensors.Communications chemistry · 2024Review
- Advances in electrochemical biosensor design for the detection of the stress biomarker cortisol.Analytical and bioanalytical chemistry · 2024Review
- Exploring the potential of molecularly imprinted polymers and metal/metal oxide nanoparticles in sensors: recent advancements and prospects.Mikrochimica acta · 2023Review
- Molecularly Imprinted Polymer-Based Biomimetic Systems for Sensing Environmental Contaminants, Biomarkers, and Bioimaging Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Sensitive dual-mode detection of carbendazim by molecularly imprinted electrochemical sensor based on biomass-derived carbon-loaded gold nanoparticles.Mikrochimica acta · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rapid and sensitive detection of steroid hormone cortisol can benefit the diagnosis of diseases related to adrenal gland disorders and chronic stress. We report a molecularly imprinted polymer (MIP)-based electrochemical sensor that utilized nano gold-doped poly o-phenylenediamine (poly-o-PD) film to selectively determine trace level cortisol with enhanced sensitivity. The sensor detected cortisol levels by measuring the current change of the redox-active probes in response to the binding of target cortisol to the imprinted sites in the polymer. The gold-doped MIP (Au@MIP) sensor was prepared using a facile one-step in situ gold reduction and electropolymerization method to distribute high-density gold nanoparticles in the vicinity of the binding cavities. The in situ gold reduction promote the polymerization reaction, enlarging the effective surface area of the sensor. The nano gold doping also facilitated charge transfer when exposed to redox reagents. It enabled efficient blocking of the charge transfer upon the occupation of the cavities by cortisol, resulting in enhanced detection response and sensitivity. The Au@MIP sensor exhibited a high affinity toward cortisol binding with a dissociation constant K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.