Evidence map›Paper›PMID 35259553›Full record

ArticleJournal of the neurological sciences2022

Genetic determinants of intracranial large artery stenosis in the northern Manhattan study.

Minghua Liu, Sanjeev Sariya, Farid Khasiyev, Giuseppe Tosto, Nicole D Dueker, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Tatjana Rundek, Mitchell S V Elkind and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracranial atherosclerotic disease and neurodegeneration: a narrative review and plausible mechanisms.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study.Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Sanjeev SariyaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Farid KhasiyevDepartment of Neurology, Saint Louis University, Saint Louis, MO, USA.
Giuseppe TostoDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Nicole D DuekerJohn P. Hussman Institute for Human Genomics, University of Miami, FL, USA.
Ying Kuen CheungDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Clinton B WrightNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Ralph L SaccoDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, FL, USA.
Tatjana RundekDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: jg3233@cumc.columbia.edu.
Columbia University · USUniversity of Miami · USDr. John T. Macdonald Foundation · USNational Institutes of Health · USSaint Louis University · US

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and dementiaR01AG057709 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2018 to 2022
$4.6M
ARCH PLAQUES AND STROKE IN AN ETHNICALLY MIXED COMMUNITYR01NS036286 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DI TULLIO, MARCO R · 1997 to 2009
$3.4M
Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's diseaseR01AG066162 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2019 to 2023
$3.1M
Vascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic RegionR56NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, RUNDEK, TATJANA · 2021 to 2021
$537k
NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS036286NINDS NIH HHS R37 NS029993NINDS NIH HHS R56 NS029993
6 · The paper itself

Abstract

backgroundIntracranial stenosis is one of the most common causes of stroke worldwide. Several single nucleotide polymorphisms have been associated with intracranial atherosclerosis, which is inferred to be the most common underlying cause of intracranial large artery stenosis (ILAS). We previously reviewed known genetic variants related to ILAS in predominantly Asian cohorts, but their prevalence and role in ILAS among western multiethnic populations are uncertain.

methodsWe leveraged existing imaging and genetic data from the Northern Manhattan Study, a multiethnic prospective cohort study. Based on literature review, we selected adiponectin Q (ADIPOQ) rs2241767 and rs182052, ring finger protein 213 (RNF213) rs112735431, apolipoprotein E (APOE) rs429358, phosphodiesterase 4D (PDE4D) rs2910829, lipoprotein lipase (LPL) rs320, and aldosterone synthase (CYP11B2) rs1799998 variants as candidates to explore. We defined ILAS as luminal stenosis >50% in any intracranial large artery using time-of-flight magnetic resonance angiography (MRA).

resultsWe included 1109 participants (mean age 70 ± 9 years, 70% Hispanic, 60% women) in this study. ILAS was identified in 81 (7%) NOMAS participants. Logistic regression analyses adjusted for age, sex, principal components, and vascular risk factors showed ILAS prevalence associated with CYP11B2 rs1799998 under the dominant model (OR = 0.56, 95%CI: 0.35-0.89) and LPL rs320 heterozygote genotype (OR = 1.68, 95%CI: 1.05-2.71). The genotype distributions of ADIPOQ rs2241767 and rs182052, APOE rs429358 and CYP11B2 rs1799998 variants were significantly different among non-Hispanic white and Black, and Hispanic groups. When participants were further stratified by race/ethnicity, the estimates were consistent for CYP11B2 rs1799998 across race/ethnic groups but not for LPL rs320.

conclusionThe CYP11B2 rs1799998 variant may be a protective genetic factor for ILAS across race/ethnic groups, but the risk of ILAS associated with LPL rs320 varies by race/ethnic group. Further functional studies may help elucidate the role that these variants play in the pathophysiology of ILAS.

Indexed as

ArteriesCytochrome P-450 CYP11B2Adenosine TriphosphatasesAgedApolipoproteins EConstriction, PathologicFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedProspective StudiesRisk FactorsUbiquitin-Protein LigasesAdenosine TriphosphatasesApolipoproteins ECytochrome P-450 CYP11B2RNF213 protein, humanUbiquitin-Protein LigasesAldosterone synthaseEpidemiologic studiesGenetic predisposition to diseaseIntracranial large artery stenosisLipoprotein lipase

Identifiers

PMID35259553
PMCPMC9018518
OpenAlexW4214951152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.