Evidence map›Paper›PMID 35259403›Full record

ArticleAnalytical biochemistry2022

How many molecules of mitochondrial complex I are in a cell?

Fariha Ansari, Belem Yoval, Zoya Niatsetskaya, Vadim Ten, Ilka Wittig, Alexander Galkin

Open access · greenAbstract read
In one paragraph

Article in Analytical biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Postnatal developmental dynamics of mitochondrial complex I in mouse tissues.American journal of physiology. Cell physiology · 2025
    Article
  3. Article
  4. Sex-dependent differences in macaque brain mitochondria.Biochimica et biophysica acta. Bioenergetics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Fariha AnsariFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Belem YovalFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Zoya NiatsetskayaDepartment of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA; Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.
Vadim TenDepartment of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA; Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.
Ilka WittigFunctional Proteomics, Institute of Cardiovascular Physiology, Goethe University, 60590, Frankfurt am Main, Germany; German Center for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Alexander GalkinFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. Electronic address: alg2057@med.cornell.edu.
Cornell University · USRutgers, The State University of New Jersey · USGoethe University Frankfurt · DE

Funding

The Role of FMN Loss by Mitochondrial Complex I in Neonatal Hypoxic-Ischemic Brain InjuryR01NS112381 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GALKIN, ALEXANDER · 2020 to 2024
$2.1M
Mitochondrial complex-I as a target for metabolic resuscitation in perinatal hypoxic-ischemic brain injuryR01NS100850 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI TEN, VADIM S · 2017 to 2021
$2.0M
Metabolic Origin of Oxidative Stress Injury in Brain Ischemia/ReperfusionR21NS125466 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GALKIN, ALEXANDER, GROSS, STEVEN S · 2022 to 2023
$466k
Ultra-sensitive multi-mode laser-scanning imaging systemS10OD030335 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2021 to 2021
$163k
NIH HHS S10 OD030335NINDS NIH HHS R01 NS100850NINDS NIH HHS R01 NS112381NINDS NIH HHS R21 NS125466
6 · The paper itself

Abstract

Mitochondrial complex I is the only enzyme responsible for oxidation of matrix NADH and regeneration of NAD

Indexed as

Electron Transport Complex IReperfusion InjuryAnimalsMiceNADOxidation-ReductionElectron Transport Complex INADAstrocytesFlavin mononucleotideFluorescenceMitochondrial complex IRespiratory chain

Identifiers

PMID35259403
PMCPMC9018534
OpenAlexW4220985847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.