Evidence map›Paper›PMID 35259021›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies.

Sarah Kono, Aafke van den Berg, Marco Simonetta, Ann Mukhortava, Elspeth F Garman, Ingrid Tessmer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sarah KonoRudolf Virchow Center, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-5267-9145
Aafke van den BergLUMICKS B.V., 1059 CH, Amsterdam, The Netherlands.ORCID 0000-0003-2991-9478
Marco SimonettaLUMICKS B.V., 1059 CH, Amsterdam, The Netherlands.
Ann MukhortavaLUMICKS B.V., 1059 CH, Amsterdam, The Netherlands.
Elspeth F GarmanDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0001-8329-5665
Ingrid TessmerRudolf Virchow Center, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-8353-6315
University of Würzburg · DEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SignificanceWe directly visualize DNA translocation and lesion recognition by the O

Indexed as

DNA RepairSingle Molecule ImagingAlkyl and Aryl TransferasesDNADNA, Single-StrandedHumansIonsModels, MolecularO(6)-Methylguanine-DNA MethyltransferaseProtein MultimerizationStructure-Activity RelationshipZincAlkyl and Aryl TransferasesDNADNA alkyltransferaseDNA, Single-StrandedIonsO(6)-Methylguanine-DNA MethyltransferaseZincDNA alkyltransferaseDNA repairfluorescence optical tweezerssingle-molecule studies

Identifiers

PMID35259021
PMCPMC8931253
OpenAlexW4221069393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.