Evidence map›Paper›PMID 35259017›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Modeling protein dynamics in

Sofia Barbieri, Aparna Nurni Ravi, Erik E Griffin, Monica Gotta

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. PLK-1 regulates MEX-1 polarization in thebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sofia BarbieriDepartment of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0000-0002-4288-5308
Aparna Nurni RaviDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-6477-1571
Erik E GriffinDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.ORCID 0000-0001-9958-2466
Monica GottaDepartment of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0000-0002-4336-7860
Dartmouth College · USUniversity of Geneva · CH

Funding

Mechanisms of Spatial Organization in the CytoplasmR01GM110194 · NIGMS · DARTMOUTH COLLEGE · PI GRIFFIN, ERIK E · 2015 to 2019
$1.6M
Mechanisms of Spatial Organization in the CytoplasmR35GM136302 · NIGMS · DARTMOUTH COLLEGE · PI GRIFFIN, ERIK E · 2020 to 2023
$1.6M
NIGMS NIH HHS R01 GM110194NIGMS NIH HHS R35 GM136302
6 · The paper itself

Abstract

SignificanceIntracellular gradients have essential roles in cell and developmental biology, but their formation is not fully understood. We have developed a computational approach facilitating interpretation of protein dynamics and gradient formation. We have combined this computational approach with experiments to understand how Polo-Like Kinase 1 (PLK-1) forms a cytoplasmic gradient in

Indexed as

ProteomeProteomicsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryo, NonmammalianModels, BiologicalMonte Carlo MethodMorphogenesisPolo-Like Kinase 1Protein Serine-Threonine KinasesProtein TransportCaenorhabditis elegans ProteinsMEX-5 protein, C elegansplk-1 protein, C elegansPolo-Like Kinase 1Protein Serine-Threonine KinasesProteomecomputational modelingintracellular gradient establishmentMEX-5polo-like kinase 1reaction–diffusion mechanisms

Identifiers

PMID35259017
PMCPMC8931239
OpenAlexW4221123071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.