Evidence map›Paper›PMID 35258782›Full record

ArticleChinese journal of integrative medicine2022

Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospital.

Yang Gao, Yan-Ming Xie, Gui-Qian Wang, Ye-Feng Cai, Xiao-Ming Shen, De-Xi Zhao, Ying-Zhen Xie, Yin Zhang, Fan-Xing Meng, Hai-Qing Yu and 2 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Chinese journal of integrative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03174535 (Risk Assessment Model for Ischemic Stroke Endpoint Events Combining Multi-dimensional Traditional Chinese Medicine), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03174535 completednot on this map

Risk Assessment Model for Ischemic Stroke Endpoint Events Combining Multi-dimensional Traditional Chinese Medicine(TCM) and Modern Medicine Indicators: a Registry Study (Inlaid With a Prospective Cohort Study to Evaluate the Effectiveness of Qilong Capsules)

Typeobservational_patient_registrySponsorChina Academy of Chinese Medical SciencesRan2016 to 2019Enrolled3,000ConditionsIschemic StrokeArmsQilong capsules (QLC), produced by Jining Huaneng Pharmaceutical Factory Co., Ltd.
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang GaoInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Yan-Ming XieInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. ktzu2018@163.com.
Gui-Qian WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Ye-Feng CaiDepartment of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China.
Xiao-Ming ShenDepartment of Neurology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China.
De-Xi ZhaoDepartment of Neurology, the Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130017, China.
Ying-Zhen XieDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Yin ZhangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Fan-Xing MengDepartment of Rehabilitation, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.
Hai-Qing YuDepartment of Neurology, Taiyuan Hospital of Traditional Chinese Medicine, Taiyuan, 140107, China.
Jun-Jie JiangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Rui-Li WeiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.

methodsA prospective, multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3, 2016 to February 17, 2019. A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors. Additionally, stroke recurrence was defined as a primary outcome indicator.

resultsA total of 327 (12.78 %) patients endured recurrence events, 1,681 (65.72%) were men, and the average age was 63.33 ± 9.45 years. Totally 1,741 (68.06%) patients suffered first-ever ischemic stroke, 1,772 (69.27%) patients reported to have hypertension, and 1,640 (64.11%) of them reported dyslipidemia, 1,595 (62.35%) patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Specifically, 1,271 (49.69%) patients were considered as qi-deficient constitution, and 1,227 (47.97%) patients were determined as stagnant blood constitution. There were 1,303 (50.94%) patients diagnosed as blood stasis syndrome, 1,280 (50.04%) patients exhibited phlegm and dampness syndrome and 1,012 (39.56%) patients demonstrated qi deficiency syndrome. And 1,033 (40.38%) patients declared intracranial artery stenosis, and 478 (18.69%) patients reported carotid artery stenosis. The plaque in 1,508 (41.36%) patients were of mixed. Particularly, 41.09% of them demonstrated abnormal levels of glycated hemoglobin levels.

conclusionsRecurrence in minor and small-artery stroke cannot be ignored. Hypertension, dyslipidemia, abnormal HbA1c, intracranial artery stenosis and carotid plaque were more common in stroke patients. Particularly, phlegm-dampness and blood stasis syndromes, as well as qi deficiency and blood stasis constitutions, were still the main manifestations of stroke. (Trial registration at ClinicalTrials.gov No. NCT03174535).

Indexed as

HypertensionIschemic StrokeStrokeAgedConstriction, PathologicFemaleHospitalsHumansMaleMedicine, Chinese TraditionalMiddle AgedProspective StudiesSyndromeChinese medicine hospitalnoncardiogenic ischemic strokeonset characteristicsrecurrence

Identifiers

PMID35258782

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.