Evidence map›Paper›PMID 35258777›Full record

ArticleNeurochemical research2022

Electro-Acupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction Via Inhibiting Mitochondrial Injury and nEuroapoptosis in Aged Rats.

Qi Zhang, Yanan Li, Chunping Yin, Jiaxu Yu, Juan Zhao, Lirong Yan, Qiujun Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Acupuncture reduced incidence of insomnia symptoms in patients with lung cancer: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qi Zhang *Department of Anesthesiology, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang City, Hebei Province, China.
Yanan Li *Department of Anesthesiology, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang City, Hebei Province, China.
Chunping YinDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang City, Hebei Province, China.
Jiaxu YuDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang City, Hebei Province, China.
Juan ZhaoExperimental Centre for Teaching of Hebei Medical University, Hebei, China.
Lirong YanSchool of Basic Medical Sciences, Hebei Medical University, Hebei, China.
Qiujun WangDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang City, Hebei Province, China. wangqiujunsy@163.com.
Hebei Medical University · CNThird Hospital of Hebei Medical University · CN

Funding

National Natural Science Foundation of China 81771134Natural Science Foundation of Hebei Province H2018206305
6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) remains one of the most common complications following anesthesia and surgery (AS) in the elderly population. Calcium-mediated mitochondrial injury has been proved to induce cognitive impairment in a variety of neurologic diseases. In the current study we determined whether electro-acupuncture (EA) pretreatment ameliorated AS-induced POCD in aged rats, as well as the underlying mechanism. Eighty SD rats (18 months, male) were randomly assigned into four groups (n = 20): C, C + EA, POCD and EA + POCD. Rats in Group POCD and EA + POCD were subjected to exploratory laparotomy under sevoflurane anesthesia. Rats of Group C + EA and EA + POCD received a 5-day EA stimulation at Hegu, Neiguan and Zusanli acupoints before AS. At 3rd day after AS, open field test along with Morris water maze test were employed to examine the cognitive function of aged rats. Then hippocampal tissues were stripped and hippocampal neuronal amount, expression level of cleaved caspase-9 level, cytochrome c (Cyt C), cleaved caspase-3 level, Bcl-2, Bax, ROS expression level, apoptosis rate, mitochondrial membrane potential (MMP), cytosolic calcium concentration ([Ca

Indexed as

Acupuncture TherapyAnesthesiaCognitive DysfunctionElectroacupuncturePostoperative Cognitive ComplicationsAgedAnimalsApoptosisbcl-2-Associated X ProteinCalciumCaspase 3Caspase 9HumansMaleProto-Oncogene Proteins c-bcl-2Ratsbcl-2-Associated X ProteinCalciumCaspase 3Caspase 9Proto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesAgedApoptosisCognitive dysfunctionElectro-acupunctureMitochondrial injury

Identifiers

PMID35258777
OpenAlexW4221040967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.