SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022
Biological augmentation of meniscal repair: a systematic review.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06541756 (Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emerging biologic augmentation strategies for meniscal repair: a systematic review.BMC musculoskeletal disorders · 2024Pooled it
- The Use of Fibrin Clot During Meniscus Repair in Young Patients Reduces Clinical Symptom Rates at 12-Month Follow-Up: A Pilot Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries.Scientific reports · 2025Trial
- Does meniscal tear morphology independently predict repair failure? A context-adjusted analysis of 500 consecutive arthroscopic meniscal repairs.Journal of experimental orthopaedics · 2026Article
- Evaluation of Spin Bias in the Use of Platelet-Rich Plasma for Augmentation of Meniscal Tear Repairs.Orthopaedic journal of sports medicine · 2026Review
- Systematic reviews in PRP-augmented meniscal repair have limited methodological quality: A systematic overview.Journal of experimental orthopaedics · 2026Article
- Fibrin Clot Augmented Meniscal Repair: A Technique to Enhance Healing After Bucket Handle Medial Meniscus Repair.Cureus · 2026Article
- Red-White Zone Involvement and Medial Meniscal Tears Are Associated with Poorer Prognosis after Arthroscopic Repair of Bucket-Handle Tears.Clinics in orthopedic surgery · 2026Article
- Current practice of biologic augmentation techniques to enhance the healing of meniscal repairs: A collaborative survey within the Meniscus International Network (MenIN) Study Group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- A Review of Revision Meniscal Repair: Clinical Considerations and Outcomes.Current reviews in musculoskeletal medicine · 2025Review
- Long-Term Results for Meniscus Repair.Current reviews in musculoskeletal medicine · 2025Review
- Growth differentiation factor 5 improves meniscal healing in a pilot study on rats.Journal of experimental orthopaedics · 2025Article
- Ultrasound-guided injection using leucocyte-rich platelet-rich plasma for treatment of meniscal injuries in a duathlete: a case report.Regenerative medicine · 2024Article
- An Insertion Device for Effective Delivery of Fibrin Clot to the Meniscus Tear.Arthroscopy techniques · 2024Article
- How to Improve Meniscal Repair through Biological Augmentation: A Narrative Review.Journal of clinical medicine · 2024Review
- The Impact of Bone Marrow Venting Augmentation on Knee Functions in the Repair of Vertical/Longitudinal Meniscus Tears: A Triple Comparison.Indian journal of orthopaedics · 2024Article
- Human-Written vs AI-Generated Texts in Orthopedic Academic Literature: Comparative Qualitative Analysis.JMIR formative research · 2024Article
- Repair of a Radial Tear of the Meniscus Augmented With a Biocomposite Scaffold.Arthroscopy techniques · 2023Article
- High survival rate after the combination of intrameniscal and intraarticular infiltrations of platelet-rich plasma as conservative treatment for meniscal lesions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOrthopedic literature remains divided on the utility of biologic augmentation to optimize outcomes after isolated meniscal repair. The aim of this systematic review is to analyze the clinical outcomes and re-operation rates of biologically augmented meniscal repairs.
methodsPubMed, CINAHL, Cochrane, and EMBASE databases were queried in October 2020 for published literature on isolated meniscal repair with biological augmentation. Studies were assessed for quality and risk of bias by two appraisal tools. Patient demographics, meniscal tear characteristics, surgical procedure, augmentation type, post-operative rehabilitation, patient reported outcome measures, and length of follow-up were recorded, reviewed, and analyzed by two independent reviewers.
resultsOf 3794 articles, 18 met inclusion criteria and yielded 537 patients who underwent biologic augmentation of meniscal repair. The biologically augmented repair rates were 5.8-27.0% with PRP augmentation, 0.0-28.5% with fibrin clot augmentation, 0.0-12.9% with marrow stimulation, and 0.0% with stem cell augmentation. One of seven studies showed lower revision rates with augmented meniscal repair compared to standard repair techniques, whereas five of seven found no benefit. Three of ten studies found significant functional improvement of biologically augmented repair versus standard repair techniques and six of ten studies found no difference. There was significant heterogeneity in methods for biologic preparation, delivery, and post-operative rehabilitation protocols.
conclusionPatients reported significant improvements in functional outcomes scores after repair with biological augmentation, though the benefit over standard repair controls is questionable. Revision rates after biologically augmented meniscal repair also appear similar to standard repair techniques. Clinicians should bear this in mind when considering biologic augmentation in the setting of meniscal repair. LEVEL OF EVIDENCE: IV.
Indexed as
Identifiers
35258647What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.