Evidence map›Paper›PMID 35258593›Full record

ArticleRheumatology (Oxford, England)2022

Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry.

Richard Conway, Elena Nikiphorou, Christiana A Demetriou, Candice Low, Kelly Leamy, John G Ryan, Ronan Kavanagh, Alexander D Fraser, John J Carey, Paul O'Connell and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 6 countries.

Richard ConwayDepartment of Rheumatology, St. James's Hospital.ORCID 0000-0003-2538-3362
Elena NikiphorouDepartment of Rheumatology.
Christiana A DemetriouDepartment of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus.
Candice LowDepartment of Rheumatology, St. Vincent's University Hospital.
Kelly LeamyDepartment of Rheumatology, Mater Misericordiae Hospital, Dublin.
John G RyanDepartment of Rheumatology, Cork University Hospital, Wilton.
Ronan KavanaghDepartment of Rheumatology, Galway Clinic, Galway.
Alexander D FraserDepartment of Rheumatology, University Hospitals Limerick.
John J CareyDepartment of Rheumatology, Galway University Hospitals.
Paul O'ConnellDepartment of Rheumatology, Beaumont Hospital.
Rachael M FloodClinical Medicine, Trinity College Dublin, Dublin, Ireland.
Ronan H MullanClinical Medicine, Trinity College Dublin, Dublin, Ireland.
David J KaneClinical Medicine, Trinity College Dublin, Dublin, Ireland.
Nicola AmbroseDepartment of Rheumatology, Blackrock Clinic, Dublin, Ireland.
Frances StaffordDepartment of Rheumatology, Blackrock Clinic, Dublin, Ireland.
Philip C RobinsonUniversity of Queensland Faculty of Medicine, Brisbane, Australia.ORCID 0000-0002-3156-3418
Jean W LiewSection of Rheumatology, Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0002-8104-2450
Rebecca GraingerDepartment of Medicine, University of Otago, Wellington, New Zealand.ORCID 0000-0001-9201-8678
Geraldine M McCarthyDepartment of Rheumatology, Mater Misericordiae Hospital, Dublin.
COVID-19 Global Rheumatology Alliance
Trinity College Dublin · IEKing's College London · GBMater Misericordiae Hospital · AUGalway Clinic · IESt. Vincent's University Hospital · IEThe University of Queensland · AUBoston University · USCork University Hospital · IEOllscoil na Gaillimhe – University of Galway · IERoyal College of Surgeons in Ireland · IEUniversity of Limerick · IEUniversity of Nicosia · CYUniversity of Otago · NZ

Funding

Department of HealthNational Institute for Health Research
6 · The paper itself

Abstract

objectivesAlthough evidence is accumulating globally, data on outcomes in rheumatic disease and COVID-19 in Ireland are limited. We used data from the COVID-19 Global Rheumatology Alliance (C19-GRA) to describe time-varying COVID-19 outcomes for people with rheumatic disease in Ireland.

methodsData entered into the C19-GRA provider registry from Ireland between 24 March 2020 and 9 July 2021 were analysed. Differences in the likelihood of hospitalization and mortality according to demographic and clinical variables were investigated using Chi-squared test or Fisher's exact test, as appropriate. Trends in odds of hospitalization and mortality over time were investigated using logistic regression with the time period as a categorical variable.

resultsOf 212 cases included, 59.4% were female and median age was 58.0 years (range 13-96). Of the 212 cases, 92 (43%) were hospitalized and 22 (10.4%) died. Increasing age, a diagnosis of gout, ever smoking, glucocorticoid use, having comorbidities and specific comorbidities of cancer, cardiovascular and pulmonary disease were more common in those hospitalized. A diagnosis of inflammatory arthritis, csDMARD and/or b/tsDMARD use were less frequent in those hospitalized. Increasing age, a diagnosis of gout, ever smoking, having comorbidities and specific comorbidities of obesity, cardiovascular and pulmonary disease were more common in those who died. Odds of hospitalization or mortality did not change over time.

conclusionNo temporal trend was observed in either COVID-19-related hospitalization or mortality outcomes for people with rheumatic disease in Ireland.

Indexed as

COVID-19GoutRheumatic DiseasesRheumatologyAdolescentAdultAgedAged, 80 and overFemaleHumansIrelandMaleMiddle AgedRegistriesSARS-CoV-2Young AdultbiologicsCOVID-19hospitalizationrheumatic disease

Identifiers

PMID35258593
PMCPMC8992296
OpenAlexW4220910825

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.