Evidence map›Paper›PMID 35258402›Full record

ArticleGut microbes

Granzyme B

Stephanie M Dillon, Kaylee L Mickens, Tezha A Thompson, Emily H Cooper, Sabrina Nesladek, Allison J Christians, Moriah Castleman, Kejun Guo, Cheyret Wood, Daniel N Frank and 3 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Cytotoxic CD4Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Stephanie M DillonDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Kaylee L MickensDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Tezha A ThompsonDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Emily H CooperDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Sabrina NesladekDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Allison J ChristiansDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Moriah CastlemanDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Kejun GuoDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Cheyret WoodDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Daniel N FrankDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Katerina KechrisDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Mario L SantiagoDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Cara C WilsonDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
University of Colorado Denver · USColorado School of Public Health · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Role of Type I IFNs in Mucosal HIV-1 Immunity and PathogenesisR01AI134220 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SANTIAGO, MARIO LUIS, WILSON, CARA C. · 2017 to 2021
$2.7M
Gut Cytotoxic CD4 T cells in HIV-1 PathogenesisR01AI145428 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SANTIAGO, MARIO LUIS, WILSON, CARA C. · 2020 to 2024
$2.2M
Mechanisms of HIV-associated Disruption of Intestinal HomeostasisR01DK088663 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 2010 to 2013
$1.6M
NCI NIH HHS P30 CA046934NIAID NIH HHS R01 AI134220NIAID NIH HHS R01 AI145428NIDDK NIH HHS R01 DK088663
6 · The paper itself

Abstract

Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating in alterations in microbial communities (dysbiosis) and increased microbial translocation. Major questions remain on how interactions between translocating microbes and gut immune cells impact HIV-1-associated gut pathogenesis. We previously reported that

Indexed as

Gastrointestinal MicrobiomeHIV-1HIV InfectionsBacteriaCD4-Positive T-LymphocytesColonDysbiosisGranzymesHumansInterleukin-2GranzymesInterleukin-2CD4 T cellsdysbiosisgranzyme BgutHIV

Identifiers

PMID35258402
PMCPMC8920224
OpenAlexW4220653984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.