Evidence map›Paper›PMID 35258327›Full record

ReviewmBio2022

Structural Dynamics and Molecular Evolution of the SARS-CoV-2 Spike Protein.

Kyle A Wolf, Jason C Kwan, Jeremy P Kamil

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kyle A WolfDepartment of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jason C KwanDepartment of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9933-1536
Jeremy P KamilDepartment of Microbiology and Immunology, Louisiana State University Health Shreveport, Shreveport, Louisiana, USA.ORCID 0000-0001-8422-7656
University of Wisconsin–Madison · USLouisiana State University · US

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
NIGMS NIH HHS P20 GM121307NIGMS NIH HHS P20 GM134974NIH HHS 3P20GM121307-04S1
6 · The paper itself

Abstract

The ongoing coronavirus disease 2019 (COVID-19) pandemic demonstrates the threat posed by novel coronaviruses to human health. Coronaviruses share a highly conserved cell entry mechanism mediated by the spike protein, the sole product of the

Indexed as

COVID-19Spike Glycoprotein, CoronavirusEvolution, MolecularHumansPeptidyl-Dipeptidase ASARS-CoV-2Peptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2adaptive mutationscoronavirusCOVID-19evolutiongenomicsglycoproteinsinfectious diseaserespiratory virusessarbecovirusSARS-CoV-2spike

Identifiers

PMID35258327
PMCPMC9040836
OpenAlexW4220686417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.