Evidence map›Paper›PMID 35258320›Full record

ArticleJournal of bacteriology2022

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis.

Oshadhi T Jayasinghe, Zachary F Mandell, Alexander V Yakhnin, Mikhail Kashlev, Paul Babitzke

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. mBio · 2025
    Article
  4. Analysis of essential genes inJournal of bacteriology · 2025
    Article
  5. Review
  6. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Biochemical characterization ofJournal of bacteriology · 2024
    Article
  11. Review
  12. Microbiology and molecular biology reviews : MMBR · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Robust regulation of transcription pausing inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Oshadhi T JayasingheDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Zachary F MandellDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Alexander V YakhninNCI RNA Biology Laboratory, Center for Cancer Research, NCI, Frederick, Maryland, USA.
Mikhail KashlevNCI RNA Biology Laboratory, Center for Cancer Research, NCI, Frederick, Maryland, USA.
Paul BabitzkeDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2481-1062
Pennsylvania State University · USCenter for Cancer Research · US

Funding

Mechanisms of transcription pausing and fidelity in prokaryotes and eukaryotesZIABC010795 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KASHLEV, MIKHAIL · 2009 to 2025
$18.1M
Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
HHS | National Institutes of Health (NIH) GM098399Intramural Research ProgramNIGMS NIH HHS R01 GM098399
6 · The paper itself

Abstract

Transcription elongation is a highly processive process that is punctuated by RNA polymerase (RNAP) pausing. Long-lived pauses can provide time for diverse regulatory events to occur, which play important roles in modulating gene expression. Transcription elongation factors can dramatically affect RNAP pausing

Indexed as

Bacillus subtilisEscherichia coli Proteins5' Untranslated RegionsBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coliPeptide Elongation FactorsTranscriptional Elongation FactorsTranscription FactorsTranscription, GeneticTranscriptome5' Untranslated RegionsBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsnusA protein, E coliNusG protein, E coliPeptide Elongation FactorsTranscriptional Elongation FactorsTranscription Factorsgene regulationNusANusGRNA polymerase pausingtranscription

Identifiers

PMID35258320
PMCPMC9112975
OpenAlexW4220985728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.