Evidence map›Paper›PMID 35258316›Full record

ArticleInfection and immunity2022

Characterization of the Phase-Variable Autotransporter Lav Reveals a Role in Host Cell Adherence and Biofilm Formation in Nontypeable Haemophilus influenzae.

Zachary N Phillips, Preeti Garai, Greg Tram, Gael Martin, Annelies Van Den Bergh, Asma-Ul Husna, Megan Staples, Keith Grimwood, Amy V Jennison, Patrice Guillon and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Inflammatory Responses to Non-TypeablePathogens (Basel, Switzerland) · 2025
    Article
  3. Phasevarions inMicrobiology spectrum · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Zachary N PhillipsInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Preeti GaraiDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Greg TramInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Gael MartinInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Annelies Van Den BerghInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Asma-Ul HusnaInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Megan StaplesQueensland Department of Health, Public Health Microbiology, Forensic and Scientific Services, Brisbane, Queensland, Australia.
Keith GrimwoodSchool of Medicine and Dentistry and Menzies Health Institute Queensland, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Amy V JennisonQueensland Department of Health, Public Health Microbiology, Forensic and Scientific Services, Brisbane, Queensland, Australia.ORCID 0000-0002-5599-7480
Patrice GuillonInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.
Mark von ItzsteinInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.ORCID 0000-0001-6302-7524
Michael P JenningsInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.ORCID 0000-0002-1027-4684
Kenneth L BrockmanDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
John M AtackInstitute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast, Queensland, Australia.ORCID 0000-0002-7994-6995
Griffith University · AUMedical College of Wisconsin · USQueensland Health · AU

Funding

Role of epigenetic regulation in the persistence of NTHI during colonization, ascension of the Eustachian tube and chronic otitis mediaR21DC016709 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BROCKMAN, KENNETH L · 2017 to 2019
$455k
NIDCD NIH HHS R21 DC016709
6 · The paper itself

Abstract

Lav is an autotransporter protein found in pathogenic Haemophilus and

Indexed as

Haemophilus InfectionsHaemophilus influenzaeBiofilmsHumansType V Secretion SystemsType V Secretion Systemsadherenceautotransporterautotransporter proteinsbiofilmbiofilmsHaemophiluslavLavphase variation

Identifiers

PMID35258316
PMCPMC9022572
OpenAlexW4220976926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.