Evidence map›Paper›PMID 35258294›Full record

ArticleJournal of the American Chemical Society2022

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement.

David C Miller, Ravi G Lal, Luca A Marchetti, Frances H Arnold

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Article
  10. Rare Gold-Catalyzed 4-Organic letters · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. MicroED Structure of a Protoglobin Reactive Carbene Intermediate.Journal of the American Chemical Society · 2023
    Article
  16. Article
  17. New Additions to the Arsenal of Biocatalysts for Noncanonical Amino Acid Synthesis.Current opinion in green and sustainable chemistry · 2022
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David C MillerDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4560-8824
Ravi G LalDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Luca A MarchettiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X
California Institute of Technology · US

Funding

Biocatalytic C-H Activation for Enantioselective Carbon-Carbon Bond FormationF32GM128247 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MILLER, DAVID C. · 2018 to 2021
$219k
NIGMS NIH HHS F32 GM128247
6 · The paper itself

Abstract

We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered "carbene transferase" enzymes. A laboratory-evolved variant of cytochrome P450

Indexed as

AzetidinesAziridinesCarbonCatalysisStereoisomerismAzetidinesAziridinesCarbon

Identifiers

PMID35258294
PMCPMC9022672
OpenAlexW4221007155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.