Evidence map›Paper›PMID 35258283›Full record

ArticleBiochemistry2022

Hysteresis in Hepatitis B Virus (HBV) Requires Assembly of Near-Perfect Capsids.

Caleb A Starr, Lauren F Barnes, Martin F Jarrold, Adam Zlotnick

Abstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caleb A StarrDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.
Lauren F BarnesDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Martin F JarroldDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0001-7084-176X
Adam ZlotnickDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0001-9945-6267

Funding

Multimode Observation of Virus Capsid AssemblyR01AI118933 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI Adam Zlotnick · 2016 to 2026
$4.0M
Single-Particle Analysis of Virus Capsids, Bacteria, and Extracellular VesiclesR35GM141922 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Stephen C Jacobson · 2021 to 2026
$3.5M
The Structural Biology of HBVR01AI144022 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI ZLOTNICK, ADAM · 2019 to 2022
$1.5M
Single-Particle Analysis of Virus Capsid Assembly and Disassembly by Resistive-Pulse SensingR01GM129354 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JACOBSON, STEPHEN C · 2018 to 2020
$925k
NIAID NIH HHS R01 AI118933NIAID NIH HHS R01 AI144022NIGMS NIH HHS R01 GM129354NIGMS NIH HHS R35 GM141922
6 · The paper itself

Abstract

The hepatitis B virus (HBV) must release its contents to initiate infection, making capsid disassembly critical to the viral life cycle. Capsid assembly proceeds through a cascade of weak interactions between copies of capsid protein (Cp) to yield uniform particles. However, there is a hysteresis to capsid dissociation that allows capsids to persist under conditions where they could not assemble. In this study, we have sought to define the basis of hysteresis by examining urea-induced dissociation of

Indexed as

CapsidHepatitis B virusCapsid ProteinsProtein ConformationVirus AssemblyCapsid Proteins

Identifiers

PMID35258283
PMCPMC9443786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.