Evidence map›Paper›PMID 35258129›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis.

Heeseog Kang, Smriti Aryal Ac, Aileen M Barnes, Aline Martin, Valentin David, Susan E Crawford, Joan C Marini

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Update on the Genetics of Osteogenesis Imperfecta.Calcified tissue international · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Heeseog KangSection on Heritable Disorders of Bone and Extracellular Matrix, NICHD, NIH, Bethesda, MD, USA.ORCID 0000-0002-2612-8585
Smriti Aryal AcSection on Heritable Disorders of Bone and Extracellular Matrix, NICHD, NIH, Bethesda, MD, USA.ORCID 0000-0001-9008-1710
Aileen M BarnesSection on Heritable Disorders of Bone and Extracellular Matrix, NICHD, NIH, Bethesda, MD, USA.ORCID 0000-0001-8021-4997
Aline MartinDivision of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-0144-9294
Valentin DavidDivision of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Susan E CrawfordDepartment of Surgery, NorthShore University HealthSystem Research Institute, Affiliate of University of Chicago Pritzker School of Medicine, Evanston, IL, USA.ORCID 0000-0003-3890-5000
Joan C MariniSection on Heritable Disorders of Bone and Extracellular Matrix, NICHD, NIH, Bethesda, MD, USA.ORCID 0000-0002-3685-0950
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNorthwestern University · USNorthShore University HealthSystem · USUniversity of Sharjah · AE

Funding

Heritable Disorders Of Connective TissueZIAHD000408 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARINI, JOAN C · 2009 to 2023
$13.4M
Role of HNF4a in the regulation of FGF23 in health and diseaseR01DK114158 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVID, NICOLAE VALENTIN · 2018 to 2021
$1.6M
Genetic Bone Disorders-Autosomal Recessive OIZ01HD008830 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARINI, JOAN C · 2007 to 2008
$982k
Intramural NIH HHS Z01 HD008830Intramural NIH HHS ZIA HD000408NIDDK NIH HHS DK114158NIDDK NIH HHS R01 DK114158
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is a heterogeneous genetic disorder of bone and connective tissue, also known as brittle bone disease. Null mutations in SERPINF1, which encodes pigment epithelium-derived factor (PEDF), cause severe type VI OI, characterized by accumulation of unmineralized osteoid and a fish-scale pattern of bone lamellae. Although the potent anti-angiogenic activity of PEDF has been extensively studied, the disease mechanism of type VI OI is not well understood. Using Serpinf1

Indexed as

Eye ProteinsNerve Growth FactorsOsteogenesis ImperfectaSerpinsTransforming Growth Factor betaAnimalsEndothelial CellsMicePigment Epithelium-Derived FactorEye ProteinsNerve Growth FactorsPigment Epithelium-Derived FactorSerpinsTransforming Growth Factor betaBONE VASCULARIZATIONMATRIX MINERALIZATIONOSTEOGENESIS IMPERFECTAPEDFTGF-β

Identifiers

PMID35258129
PMCPMC11152058
OpenAlexW4220707826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.