Evidence map›Paper›PMID 35257948›Full record

SynthesisAnnals of physical and rehabilitation medicine2023

Risk factors for rotator cuff disease: A systematic review and meta-analysis of diabetes, hypertension, and hyperlipidemia.

Ayush Giri, Deirdre O'Hanlon, Nitin B Jain

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Annals of physical and rehabilitation medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07645963 (Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07645963 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled36ConditionsRotator Cuff SyndromeArmsMyofascial Trigger Point Release (MFTR)+ conservative physiotherapy Group, Neil Asher Technique (NAT) + conservative physiotherapy Group
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  8. Animal models of diabetes-related shoulder disorders.Frontiers in veterinary science · 2026
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ayush GiriDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: ayush.giri@vumc.org.
Deirdre O'HanlonUniversity of Rochester School of Medicine, Rochester, NY, USA.
Nitin B JainDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Orthopedics, and Population and Data Sciences, University of Texas Southwestern, Dallas, TX, United States of America.
The University of Texas Southwestern Medical Center · USUniversity of Rochester · USVanderbilt University Medical Center · US

Funding

Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
The Genetic Epidemiology of Rotator Cuff Tears: the cuffGEN Study - SupplementR01AR074989 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAIN, NITIN B · 2020 to 2025
$3.6M
Influence of genetic variation, genetic ancestry, and obesity on gestational diabetes mellitus riskK01DK120631 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GIRI, AYUSH · 2020 to 2022
$422k
NIAMS NIH HHS R01 AR074989NICHD NIH HHS K12 HD043483NIDDK NIH HHS K01 DK120631
6 · The paper itself

Abstract

backgroundRotator cuff disease is a common cause of shoulder pain. Comorbidities such as diabetes, hypertension, and hyperlipidemia may be associated with rotator cuff disease, likely because of mechanisms related to vascular insufficiency.

objectivesWe performed a systematic review of the association of diabetes, hypertension, and hyperlipidemia with the diagnosis of rotator cuff disease.

methodsFollowing systematic queries of PubMed, Embase, Cochrane, CINAHL, and Science Direct, articles meeting eligibility criteria and reporting on the association of one or more risk factors (diabetes, hypertension, and hyperlipidemia) and rotator cuff disease were considered. Meta-analysis was performed to quantitatively summarize the associations between each risk factor and rotator cuff disease. We assessed study quality with the Newcastle-Ottawa Scale (NOS) and performed a qualitative assessment of risk of bias.

resultsAfter a full-text review of 212 articles, 12 articles assessing diabetes, 5 assessing hypertension and 8 assessing hyperlipidemia were eligible. The odds of having rotator cuff disease was increased with diabetes (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.43-1.55), hypertension (OR 1.40, 95% CI 1.19-1.65) and hyperlipidemia/dyslipidemia (OR 1.48, 95% CI 1.42-1.55). Diabetes was also specifically associated with rotator cuff tears (OR 1.28, 95% CI 1.07-1.52). Synthesizing assessment for risk of bias suggested that current epidemiologic evidence for an association was plausible for diabetes and hyperlipidemia but not hypertension.

conclusionsDiabetes, hypertension, and hyperlipidemia were associated with rotator cuff disease in our meta-analysis. However, the possibility of bias exists for all 3 co-morbidities evaluated and is likely highest for hypertension. High-quality studies with the ability to incorporate time since first diagnosis of co-morbidity are scarce and much needed.

Indexed as

Diabetes MellitusHyperlipidemiasRotator Cuff InjuriesArthroscopyHumansRisk FactorsRotator CuffTreatment Outcomediabeteshyperlipidemiahypertensionmeta-analysisobservational studiesrotator cuff diseaserotator cuff tearssystemtic review

Identifiers

PMID35257948
PMCPMC9974529
OpenAlexW4220788869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.