Evidence map›Paper›PMID 35257662›Full record

ArticleeLife2022

The ACF chromatin-remodeling complex is essential for Polycomb repression.

Elizabeth T Wiles, Colleen C Mumford, Kevin J McNaught, Hideki Tanizawa, Eric U Selker

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Article
  6. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The RPD3L deacetylation complex is required for facultative heterochromatin repression inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elizabeth T WilesInstitute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0001-7269-7466
Colleen C MumfordInstitute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0003-0213-0901
Kevin J McNaughtInstitute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0002-6887-3161
Hideki TanizawaInstitute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0002-2573-2473
Eric U SelkerInstitute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0001-6465-0094
University of Oregon · US

Funding

DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Control and function of heterochromatin in Neurospora crassaR35GM127142 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2018 to 2022
$2.6M
Control and Function of Histone H3 Lysine 27 Methylation in NeurosporaR01GM093061 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2012 to 2015
$1.1M
NICHD NIH HHS T32 HD007348NIGMS NIH HHS R01 GM093061NIGMS NIH HHS R35 GM127142
6 · The paper itself

Abstract

Establishing and maintaining appropriate gene repression is critical for the health and development of multicellular organisms. Histone H3 lysine 27 (H3K27) methylation is a chromatin modification associated with repressed facultative heterochromatin, but the mechanism of this repression remains unclear. We used a forward genetic approach to identify genes involved in transcriptional silencing of H3K27-methylated chromatin in the filamentous fungus

Indexed as

Drosophila ProteinsNucleosomesChromatinHeterochromatinPolycomb-Group ProteinsChromatinDrosophila ProteinsHeterochromatinNucleosomesPolycomb-Group Proteinschromatin remodelerchromosomesfacultative heterochromatingene expressiongeneticsgenomicsH3K27 methylationISWIN. crassanucleosome positioningPRC2

Identifiers

PMID35257662
PMCPMC9038196
OpenAlexW4220980490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.