ArticleeLife2022
Critical role for isoprenoids in apicoplast biogenesis by malaria parasites.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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Who cites it
38 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- A cytoskeleton-associated Plasmodium protein critical for organelle segregation.Nature communications · 2026Article
- Evolutionary Rate Covariation Across Malaria Parasite Species Enables Inference of Protein Interactions.Genome biology and evolution · 2026Article
- Identification of a Putative Metal Transporter in the Apicoplast of Malaria Parasites.bioRxiv : the preprint server for biology · 2026Article
- Acyl Carrier Protein is Essential for Apicoplast Biogenesis in Malaria Parasites Independent of Fatty Acid Synthesis.bioRxiv : the preprint server for biology · 2026Article
- Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites.PLoS pathogens · 2026Review
- Evolutionary divergence and functional insights into the heteromeric cis-prenyltransferase of Paramecium tetraurelia.The FEBS journal · 2026Article
- Evolutionary rate covariation across malaria parasite species enables inference of protein interactions.bioRxiv : the preprint server for biology · 2026Article
- An essential adaptor for apicoplast fission and inheritance in malaria parasites.Nature communications · 2025Article
- Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification.International journal of molecular sciences · 2025Review
- Recent advances in microbially derived chlorinated antiparasitic compounds.Molecular diversity · 2025Review
- An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites.bioRxiv : the preprint server for biology · 2025Article
- Decoding the Minimal Translation System of the Plasmodium falciparum Apicoplast: Essential tRNA-modifying Enzymes and Their Roles in Organelle Maintenance.Journal of molecular biology · 2025Article
- Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin.Research square · 2025Article
- Biogenesis of CytochromesACS infectious diseases · 2025Article
- The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission inmBio · 2025Article
- Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery.Current topics in medicinal chemistry · 2025Review
- Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.eLife · 2024Article
- Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biogenesis of cytochromesbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Megan OkadaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID 0000-0003-4398-9819
Krithika RajaramDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, United States.ORCID 0000-0003-4830-5471
Russell P SwiftDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, United States.
Amanda MixonDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
John Alan MaschekMetabolomics Core, University of Utah Health Sciences Center, Salt Lake City, United States.
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, United States.ORCID 0000-0001-9684-1733
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID 0000-0002-3464-3042
University of Utah · USJohns Hopkins University · US
Funding
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9MProteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6MRESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4MDeterminants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9MComparative Heme Metabolism in Divergent EukaryotesR35GM133764 · NIGMS · UNIVERSITY OF UTAH · PI SIGALA, PAUL A · 2019 to 2023
$2.1MAgilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578kQ-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530kAgilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401kNIAID NIH HHS R01 AI125534NIAID NIH HHS T32 AI007417NIDDK NIH HHS T32 DK007115NIDDK NIH HHS U54 DK110858NIGMS NIH HHS R35 GM133764NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505
Abstract
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in
Indexed as
ApicoplastsMalaria, FalciparumParasitesAnimalsPlasmodium falciparumPolyprenolsProtozoan ProteinsTerpenesPolyprenolsProtozoan ProteinsTerpenesapicoplastbiochemistrychemical biologyinfectious diseaseisoprenoidsmalariamicrobiologyorganelle biogenesisP. falciparumpolyprenol synthase
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.