Evidence map›Paper›PMID 35257514›Full record

ArticleJournal of biomedical materials research. Part A2022

Photocurable antimicrobial silk-based hydrogels for corneal repair.

Inês A Barroso, Kenny Man, Thomas J Hall, Thomas E Robinson, Sophie E T Louth, Sophie C Cox, Anita K Ghag

Open access · hybridAbstract read
In one paragraph

Article in Journal of biomedical materials research. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  5. Biomaterials for Corneal Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Review
  8. Photocurable antimicrobial silk-based hydrogels for corneal repair.Journal of biomedical materials research. Part A · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Inês A BarrosoSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.
Kenny ManSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0002-7946-9375
Thomas J HallSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.
Thomas E RobinsonSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.
Sophie E T LouthSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0003-3065-8201
Sophie C CoxSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0003-4746-0322
Anita K GhagSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0002-6650-3394
University of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal transplantation is the current gold standard treatment to restore visual acuity to patients with severe corneal diseases and injuries. Due to severe donor tissue shortage, efforts to develop a corneal equivalent have been made but the challenge remains unmet. Another issue of concern in ocular surgery is the difficult instillation and fast drainage of antibiotic ocular eye drops as bacterial infections can jeopardize implant success by delaying or impairing tissue healing. In this study, we developed antimicrobial silk-based hydrogels that have the potential to be photoactivated in situ, fully adapting to the corneal injury shape. Gentamicin-loaded methacrylated-silk (SilkMA) hydrogels were prepared within minutes using low UV intensity (3 mW/cm

Indexed as

Anti-Infective AgentsFibroinsAnti-Bacterial AgentsCorneaHumansHydrogelsSilkTissue EngineeringAnti-Bacterial AgentsAnti-Infective AgentsFibroinsHydrogelsSilkantimicrobialcornearegenerative medicinesilk fibroin

Identifiers

PMID35257514
PMCPMC9313849
OpenAlexW4220728995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.