Evidence map›Paper›PMID 35257504›Full record

ArticlePharmacology research & perspectives2022

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor.

James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O'Donoghue, Amber Bahr, Elisa de Stanchina, Nagavarakishore Pillarsetty, John L Humm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

James RussellDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-0827-1801
Louise FanchonDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hanan AlwaseemThe Proteomics Resource Center, The Rockefeller University, New York, New York, USA.
Henrik MolinaThe Proteomics Resource Center, The Rockefeller University, New York, New York, USA.
Isabella O'DonoghueDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Amber BahrAnti-Tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Elisa de StanchinaAnti-Tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nagavarakishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Memorial Sloan Kettering Cancer Center · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MSKCC Pilot Center for Precision Disease ModelingU54OD020355 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SOLIT, DAVID B. · 2015 to 2019
$9.9M
Imaging drug uptake and distribution in chemoradiation therapy of pancreatic cancerR01CA194321 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HUMM, JOHN L, PILLARSETTY, NAGAVARAKISHORE · 2016 to 2019
$2.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA194321NIH HHS U54 OD020355
6 · The paper itself

Abstract

Previously published digital autoradiography of

Indexed as

Pancreatic NeoplasmsProdrugsAnimalsAutoradiographyCapecitabineDisease Models, AnimalHumansMiceCapecitabineProdrugsautoradiographycapecitabinegemcitabineLC-MSpancreatic cancer

Identifiers

PMID35257504
PMCPMC8902142
OpenAlexW4220797619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.