Evidence map›Paper›PMID 35257501›Full record

GuidelineArthritis & rheumatology (Hoboken, N.J.)2022

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.

Mark Gorelik, Sharon A Chung, Kaveh Ardalan, Bryce A Binstadt, Kevin Friedman, Kristen Hayward, Lisa F Imundo, Sivia K Lapidus, Susan Kim, Mary Beth Son and 31 more

Open access · greenAbstract readPractice Guideline
In one paragraph

Guideline in Arthritis & rheumatology (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 2 countries.

Mark GorelikColumbia University School of Medicine, New York, New York.
Sharon A ChungUniversity of California, San Francisco.ORCID 0000-0002-2238-2287
Kaveh ArdalanDuke University School of Medicine, Durham, North Carolina.ORCID 0000-0001-5075-8846
Bryce A BinstadtUniversity of Minnesota, Minneapolis.
Kevin FriedmanBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Kristen HaywardSeattle Children's Hospital and University of Washington School of Medicine, Seattle, Washington.
Lisa F ImundoColumbia University School of Medicine, New York, New York.
Sivia K LapidusJoseph M. Sanzari Children's Hospital, Hackensack University Medical Center, and Hackensack Meridian School of Medicine, Hackensack, New Jersey.ORCID 0000-0001-8452-9937
Susan KimUniversity of California, San Francisco.ORCID 0000-0003-2159-8059
Mary Beth SonBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-7394-2862
Sangeeta SuleChildren's National Hospital, Washington, DC.ORCID 0000-0002-5876-376X
Adriana H TremouletRady Children's Hospital and University of California, San Diego.
Heather Van MaterDuke University School of Medicine, Durham, North Carolina.
Cagri Yildirim-TorunerBaylor College of Medicine, Houston, Texas.
Carol A LangfordCleveland Clinic Foundation, Cleveland, Ohio.
Mehrdad MazUniversity of Kansas Medical Center, Kansas City.ORCID 0000-0002-3594-0508
Andy AbrilMayo Clinic, Jacksonville, Florida.
Gordon GuyattMcMaster University, Hamilton, Ontario, Canada.
Amy M ArcherNorthwestern University, Chicago, Illinois.
Doyt L ConnEmory University, Atlanta, Georgia.ORCID 0000-0003-3303-3944
Kathy A FullSpringfield, Illinois.
Peter C GraysonNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.ORCID 0000-0002-8269-9438
Maria F IbarraChildren's Mercy Hospital, Kansas City, Missouri.
Peter A MerkelUniversity of Pennsylvania, Philadelphia.
Rennie L RheeUniversity of Pennsylvania, Philadelphia.ORCID 0000-0002-4907-0304
Philip SeoJohns Hopkins Medical Institute, Baltimore, Maryland.
John H StoneMassachusetts General Hospital, Boston.ORCID 0000-0001-6588-9435
Robert P SundelBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Omar I VitobaldiChicago, Illinois.
Ann WarnerSaint Luke's Health System, Kansas City, Missouri.
Kevin ByramVanderbilt University, Nashville, Tennessee.
Anisha B DuaNorthwestern University, Chicago, Illinois.ORCID 0000-0002-3508-9290
Nedaa HusainatSSM Health St. Mary's Hospital, St. Louis, Missouri.ORCID 0000-0002-9638-2992
Karen E JamesUniversity of Utah, Salt Lake City.
Mohamad KalotState University of New York at Buffalo.
Yih Chang LinUniversity of South Florida, Tampa.
Jason M SpringerVanderbilt University, Nashville, Tennessee.
Marat TurgunbaevAmerican College of Rheumatology, Atlanta, Georgia.
Alexandra Villa-ForteCleveland Clinic Foundation, Cleveland, Ohio.
Amy S TurnerAmerican College of Rheumatology, Atlanta, Georgia.ORCID 0000-0001-7695-2022
Reem A MustafaUniversity of Kansas Medical Center, Kansas City.ORCID 0000-0002-2091-0875
Boston Children's Hospital · USAmerican College of Rheumatology · USCleveland Clinic · USColumbia University · USDuke University · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Kansas Medical Center · USUniversity of Pennsylvania · USVanderbilt University · USBaylor College of Medicine · USChildren's Mercy Hospital · USChildren's National · USEmory University · USHackensack University Medical Center · USJacksonville College · USJohns Hopkins University · USMassachusetts General Hospital · USMcMaster University · CANational Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2M
Vasculitis and Translational MedicineZIAAR041204 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GRAYSON, PETER · 2015 to 2025
$15.4M
Intramural NIH HHS Z99 AR999999
6 · The paper itself

Abstract

objectiveTo provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists.

methodsSixteen clinical questions regarding diagnostic testing, treatment, and management of KD were developed in the Patient/Population, Intervention, Comparison, and Outcomes (PICO) question format. Systematic literature reviews were conducted for each PICO question. We used the Grading of Recommendations, Assessment, Development and Evaluation method to assess the quality of evidence and formulate recommendations. Each recommendation required consensus from at least 70% of the Voting Panel.

resultsWe present 1 good practice statement, 11 recommendations, and 1 ungraded position statement to guide the management of KD and clinical scenarios of suspected KD. These recommendations for KD are focused on situations in which input from rheumatologists may be requested by other managing specialists, such as in cases of treatment-refractory, severe, or complicated KD. The good practice statement affirms that all patients with KD should receive initial treatment with intravenous immunoglobulin (IVIG). In addition, we developed 7 strong and 4 conditional recommendations for the management of KD or suspected KD. Strong recommendations include prompt treatment of incomplete KD, treatment with aspirin, and obtaining an echocardiogram in the setting of unexplained macrophage activation syndrome or shock. Conditional recommendations include use of IVIG with other adjuvant agents for patients with KD and high-risk features of IVIG resistance and/or coronary artery aneurysms. These recommendations endorse minimizing risk to the patient by using established therapy promptly at disease onset and identifying situations in which adjunctive therapy may be warranted.

conclusionThese recommendations provide guidance regarding diagnostic strategies, use of pharmacologic agents, and use of echocardiography in patients with suspected or confirmed KD.

Indexed as

Mucocutaneous Lymph Node SyndromeRheumatologyEvidence-Based MedicineHumansImmunoglobulins, IntravenousImmunosuppressive AgentsUnited StatesImmunoglobulins, IntravenousImmunosuppressive Agents

Identifiers

PMID35257501
PMCPMC12326508
OpenAlexW4220950797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.