Evidence map›Paper›PMID 35257397›Full record

ArticleAlcoholism, clinical and experimental research2022

Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self-reported opioid use among a national cohort of patients with HIV.

Benjamin J Oldfield, Yu Li, Rachel Vickers-Smith, Declan T Barry, Stephen Crystal, Kirsha S Gordon, Robert D Kerns, Emily C Williams, Brandon D L Marshall, E Jennifer Edelman

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Benjamin J OldfieldFair Haven Community Health Care, New Haven, Connecticut, USA.ORCID 0000-0003-1708-803X
Yu LiBrown University School of Public Health, Providence, Rhode Island, USA.
Rachel Vickers-SmithDepartment of Epidemiology, University of Kentucky College of Public Health, Lexington, Kentucky, USA.ORCID 0000-0002-7224-8916
Declan T BarryYale School of Medicine, New Haven, Connecticut, USA.
Stephen CrystalCenter for Health Services Research, Institute for Health, Rutgers University, Rutgers, New Jersey, USA.
Kirsha S GordonYale School of Medicine, New Haven, Connecticut, USA.
Robert D KernsYale School of Medicine, New Haven, Connecticut, USA.
Emily C WilliamsDepartment of Health Systems and Population Health, University of Washington School of Public Health, Seattle, Washington, USA.
Brandon D L MarshallBrown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0002-0134-7052
E Jennifer EdelmanYale School of Medicine, New Haven, Connecticut, USA.
Yale University · USBrown University · USRutgers, The State University of New Jersey · USUniversity of Kentucky · USWashington State Department of Health · US

Funding

Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
The HIV and Alcohol Research center focused on Polypharmacy (HARP)P01AA029545 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2021 to 2025
$6.3M
Non-Medical Use of Prescription Opioids Among HIV-Infected Individuals: Trajectories and Impact on Health OutcomesR01DA040471 · NIDA · YALE UNIVERSITY · PI EDELMAN, E. JENNIFER · 2016 to 2018
$716k
NIAAA NIH HHS P01 AA029545NIAAA NIH HHS U01 AA020790NIDA NIH HHS R01 DA040471
6 · The paper itself

Abstract

backgroundHeavy episodic drinking (HED) is a risk factor for opioid-related overdose and negatively impacts HIV disease progression. Among a national cohort of patients with HIV (PWH), we examined sociodemographic and clinical correlates of concomitant HED and self-reported opioid use.

methodsWe used data collected from 2002 through 2018 from the Veterans Aging Cohort Study, a prospective cohort including PWH in care at eight US Veterans Health Administration sites. HED was defined as consuming six or more drinks at least once in the year prior to survey collection. We examined the relationship between HED and self-reported opioid use and created a 4-level composite variable of HED and opioid use. We used multinomial logistic regression to estimate odds of reporting concomitant HED and self-reported opioid use.

resultsAmong 3702 PWH, 1458 (39.4%) reported HED during the study period and 350 (9.5%) reported opioid use. In the multinomial model, compared to reporting neither HED nor opioid use, lifetime housing instability (adjusted odds ratio [aOR] 1.54, 95% confidence interval [CI] 1.01 to 2.35), Veterans Aging Cohort Study Index 2.0 (a measure of disease severity; aOR 1.14, 95% CI 1.02 to 1.28), depressive symptoms (aOR 2.27, 95% CI 1.42 to 3.62), past-year cigarette smoking (aOR 3.06, 95% CI 1.53 to 6.14), cannabis use (aOR 1.69, 95% CI 1.09 to 2.62), and cocaine/stimulant use (aOR 11.54, 95% CI 7.40 to 17.99) were independently associated with greater odds of concomitant HED and self-reported opioid use. Compared to having attended no college, having some college or more (aOR 0.39, 95% CI 0.26 to 0.59) was associated with lower odds of concomitant HED and self-reported opioid use.

conclusionsAmong PWH, concomitant HED and self-reported opioid use are more common among individuals with depressive symptoms and substance use, structural vulnerabilities, and greater illness severity. Efforts to minimize opioid-related risk should address high-risk drinking as a modifiable risk factor for harm among these groups.

Indexed as

Cocaine-Related DisordersHIV InfectionsOpioid-Related DisordersAlcohol DrinkingAnalgesics, OpioidCohort StudiesHumansPrevalenceProspective StudiesSelf ReportAnalgesics, Opioidalcohol-related disorderscohort studiesdrug overdosehuman immunodeficiency virusopioid-related disorders

Identifiers

PMID35257397
PMCPMC9018502
OpenAlexW4220976624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.