ArticleBrain imaging and behavior2022
Spontaneous neural activity in the right fusiform gyrus and putamen is associated with consummatory anhedonia in obsessive compulsive disorder.
Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 15 citations in OpenAlex.
- Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.Translational psychiatry · 2025Article
- Abnormal Structure-Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia.Depression and anxiety · 2025Article
- Reward network mechanism in anhedonia and depression.PloS one · 2025Article
- Shared and Unique Structural Covariance Connectivity in Comorbidity of Obsessive-Compulsive Disorder and Major Depressive Disorder.Depression and anxiety · 2025Article
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8 authors at 1 institution in 2 countries.
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Abstract
backgroundAccumulating evidence indicated that anhedonia as a transdiagnostic construct might be an inherent feature of obsessive-compulsive disorder(OCD). Moreover, our recent study demonstrated that OCD patients exhibited consummatory anhedonia but not anticipatory anhedonia. However, neural mechanisms of consummatory anhedonia in OCD has not been explored. This study aimed to investigate this issue using resting-state functional magnetic resonance imaging (fMRI).
methods44 OCD patients with high consummatory anhedonia(OCD-HCA), 41 OCD patients with low consummatory anhedonia(OCD-LCA) and 47 healthy controls (HC) underwent fMRI scan. Spontaneous neural activity was analyzed and compared among the three groups by adopting the amplitude of low-frequency fluctuation (ALFF). Relationships between the consummatory anhedonia levels and regional ALFFs were examined in OCD patients.
resultsCompared with HC, OCD-HCA showed decreased ALFF in the right putamen and right thalamus, and OCD-LCA showed increased ALFF in the right orbitofrontal cortex and decreased ALFF in the right fusiform gyrus, left Precentral/postcentral gyrus. Notably, ALFF values differed between the two patient groups in the right putamen (OCD-HCA < OCD-LCA), and right fusiform gyrus (OCD-HCA > OCD-LCA). Further analysis revealed that the consummatory anhedonia was positively correlated with ALFF values in the right fusiform, and negatively correlated with ALFFs in the right putamen.
conclusionsSpontaneous neural activity in right fusiform gyrus and right putamen is associated with consummatory anhedonia in OCD. The findings provided first insights into neural mechanism of consummatory anhedonia in OCD and confirmed the importance of exploring the transdiagnostic role of anhedonia.
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