ArticleClinical oral investigations2022
The effects of mouthwashes in human gingiva epithelial progenitor (HGEPp) cells.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials.PloS one · 2023Pooled it
- Efficacy of Mouthwashes Delivered via Dental Unit Waterlines in Reducing Aerosolized Surrogate SARS-CoV-2.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Residuals of Chemical Cleaning Agents Impair Peri-Implant Cell Viability: An in Vitro Study.ACS biomaterials science & engineering · 2026Article
- In vitro analysis of various mouthwashes: cytotoxic, apoptotic, genotoxic and antibacterial effects.Clinical oral investigations · 2025Article
- New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry.Molecules (Basel, Switzerland) · 2024Review
- Ingredients in Commercially Available Mouthwashes.International dental journal · 2024Review
- Effect of sodium hypochlorite gel on bacteria associated with periodontal disease.Clinical oral investigations · 2024Article
- Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products.Biomimetics (Basel, Switzerland) · 2022Review
- Evidence on the Use of Mouthwash for the Control of Supragingival Biofilm and Its Potential Adverse Effects.Antibiotics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe gingiva epithelium accounts for a significant proportion of the surface around the tooth. An inflammatory reaction occurs in the presence of bacterial biofilm, adhesion is reduced, and the depth of the sulcus gingivalis increases. The most common antiseptic agents in oral rinses are chlorhexidine digluconate (CHX) and cetylpyridinium chloride. We examined long-lasting effects of residual concentrations of eight commercially available rinses. Our main goals were (i) to analyze the effect of different chemical compositions on cell proliferation, (ii) to examine apoptosis, and (iii) cell morphology on human epithelial progenitor cell line (HGEPp). MATERIALS AND
methodsCell proliferation was measured in a real-time system (0-48 h) by impedimetry (xCELLigence). Apoptosis was measured with labeled Annexin-V (BD-FACScalibur).
resultsChanges in proliferation were measured at certain concentrations: (i) H
conclusionsMouthwashes and their reference compounds proved to have concentration-dependent cytotoxic effects on human gingival epithelial cells. CLINICAL RELEVANCE: A better understanding of the effects of mouthwashes and their reference compounds is particularly important. These concentration-dependent effects (cytotoxic or proliferation inducing) interfere with human cells physiology while being used in the fight against the pathogenic flora.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.