Evidence map›Paper›PMID 35257215›Full record

ArticleMikrochimica acta2022

Heparin-enhanced peroxidase-like activity of iron-cobalt oxide nanosheets for sensitive colorimetric detection of trypsin.

Chenyu Zhou, Junyang Chen, Guannan Wang, Xingguang Su

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. RSC advances · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chenyu ZhouDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Junyang ChenDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Guannan WangCollege of Medical Engineering, Jining Medical University, Jining, 272067, People's Republic of China. chemwangguannan@126.com.
Xingguang SuDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China. suxg@jlu.edu.cn.
Jilin University · CNJining Medical University · CN

Funding

National Natural Science Foundation of China No. 21575048National Natural Science Foundation of China No. 21775052Science and Technology Development project of Jilin province, China No. 20180414013GH
6 · The paper itself

Abstract

Iron-cobalt oxide nanosheets (FeCo-ONSs) were proved to have intrinsic peroxidase-like activity. Additionally, the peroxidase-like activity of FeCo-ONSs toward the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) was dramatically enhanced after heparin addition due to the stronger affinity toward TMB. Protamine combines with heparin, so the promotion of peroxidase-like activity of FeCo-ONSs with heparin was suppressed. With the addition of trypsin, protamine was hydrolyzed and the enhancement effect of catalytic activity of FeCo-ONSs was recovered. Based on above process, a sensitive colorimetric platform for trypsin activity determination was constructed through measuring the absorbance of produced oxTMB at 652 nm, providing a linear detection range of 5 to 500 ng/mL and a low detection limit of 2.8 ng/mL. The method was applied to trypsin determination in real samples (human urine sample and multienzyme tablet sample) with satisfactory results, illustrating the potential application of this biosensor.

Indexed as

ColorimetryPeroxidaseCobaltHeparinHumansIronOxidesOxidoreductasesPeroxidasesProtaminesTrypsinCobaltcobalt oxideHeparinIronOxidesOxidoreductasesPeroxidasePeroxidasesProtaminesTrypsinColorimetric detectionIron-cobalt oxide nanosheetsPeroxidase-like activityTrypsin activity

Identifiers

PMID35257215
OpenAlexW4220903496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.