Evidence map›Paper›PMID 35257103›Full record

ArticleJACC. Case reports2022

Missense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation.

Wolfgang Poller, Felicitas Escher, Jan Haas, Bettina Heidecker, Heinz-Peter Schultheiss, Philipp Attanasio, Carsten Skurk, Arash Haghikia, Benjamin Meder, Sabine Klaassen

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Article
  4. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Wolfgang PollerDepartment of Cardiology, Campus Benjamin Franklin, Charité Centrum 11, Berlin, Germany.
Felicitas EscherDepartment of Cardiology, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jan HaasDepartment of Cardiology, University Hospital Heidelberg, Mannheim, Germany.
Bettina HeideckerDepartment of Cardiology, Campus Benjamin Franklin, Charité Centrum 11, Berlin, Germany.
Heinz-Peter SchultheissInstitute for Clinical Diagnostics and Therapy (IKDT), Berlin, Germany.
Philipp AttanasioDepartment of Cardiology, Campus Benjamin Franklin, Charité Centrum 11, Berlin, Germany.
Carsten SkurkDepartment of Cardiology, Campus Benjamin Franklin, Charité Centrum 11, Berlin, Germany.
Arash HaghikiaDepartment of Cardiology, Campus Benjamin Franklin, Charité Centrum 11, Berlin, Germany.
Benjamin MederDepartment of Cardiology, University Hospital Heidelberg, Mannheim, Germany.
Sabine KlaassenGerman Center for Cardiovascular Research (DZHK), Berlin, Germany.
German Centre for Cardiovascular Research · DECharité - Universitätsmedizin Berlin · DECS Diagnostics · DEStanford University · USUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. (

Indexed as

CAD, coronary artery diseaseCMP, cardiomyopathyDCM, dilated cardiomyopathyEMB, endomyocardial biopsyinflammationinnate immune responseion channel diseasesion channel functionsLVEF, left ventricular ejection fractionLV, left ventricleLVMi, left ventricular mass indexMRI, magnetic resonance imagingPBMC, peripheral blood mononuclear cellsPCR, polymerase chain reactionRT-PCR, reverse transcriptase polymerase chain reactionSCD, sudden cardiac deathSCN5A, sodium voltage-gated channel alpha subunit 5variant screeningVES, ventricular extrasystoleVF, ventricular fibrillationVT, ventricular tachycardia

Identifiers

PMID35257103
PMCPMC8897185
OpenAlexW4214912490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.