Evidence map›Paper›PMID 35257054›Full record

ArticleKidney international reports2022

Sex-Specific Differences in Mortality and Incident Dialysis in the Chronic Kidney Disease Outcomes and Practice Patterns Study.

Manfred Hecking, Charlotte Tu, Jarcy Zee, Brian Bieber, Sebastian Hödlmoser, Helmut Reichel, Ricardo Sesso, Friedrich K Port, Bruce M Robinson, Juan Jesus Carrero and 4 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Sex and Gender Disparities in Kidney Transplantation.Advances in kidney disease and health · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. One-year Survival of End-Stage Kidney Disease Patients Undergoing Hemodialysis in Indonesia.International journal of nephrology and renovascular disease · 2025
    Article
  11. Article
  12. Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Inequities in kidney health and kidney care.Nature reviews. Nephrology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 7 countries.

Manfred HeckingClinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Charlotte TuArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Jarcy ZeeArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Brian BieberArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Sebastian HödlmoserDepartment of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.
Helmut ReichelNephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Germany.
Ricardo SessoNephrology Division, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
Friedrich K PortArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Juan Jesus CarreroDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Allison TongClinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Christian CombeService de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Bénédicte StengelUniversité Paris-Saclay, UVSQ, Institut National de la Santé et de la Recherche Médicale, Clinical Epidemiology Team, CESP (Research Center in Epidemiology and Population Health), Villejuif, France.
Roberto Pecoits-FilhoArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Arbor Research Collaborative for Health · USMedical University of Vienna · ATCentre Hospitalier Universitaire de Bordeaux · FRInserm · FRKarolinska Institutet · SENephrologisches Zentrum Villingen-Schwenningen · DEUniversidade Federal de São Paulo · BRUniversity of Sydney · AU

Funding

Austrian Science Fund FWF KLI 754
6 · The paper itself

Abstract

Introduction: More men than women start kidney replacement therapy (KRT) although the prevalence of chronic kidney disease (CKD) is higher in women than men. We therefore aimed at analyzing sex-specific differences in clinical outcomes among 8237 individuals with CKD in stages 3 to 5 from Brazil, France, Germany, and the United States participating in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps). Methods: Fine and Gray models, evaluating the effect of sex on time to events, were adjusted for age, Black race (model A); plus diabetes, cardiovascular disease, albuminuria (model B); plus estimated glomerular filtration rate (eGFR) slope during the first 12 months after enrollment and first eGFR after enrollment (model C). Results: There were more men than women at baseline (58% vs. 42%), men were younger than women, and men had higher eGFR (28.9 ± 11.5 vs. 27.0 ± 10.8 ml/min per 1.73 m Conclusion: Men had a higher probability of commencing dialysis before death, unexplained by CKD progression alone. Although the causal mechanisms are uncertain, this finding helps interpret the preponderance of men in the dialysis population.

Indexed as

chronic kidney diseasecompeting risksgender disparitykidney replacement therapymortalitysex-specific differences

Identifiers

PMID35257054
PMCPMC8897674
OpenAlexW3216543397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.