Evidence map›Paper›PMID 35256931›Full record

ReviewActa pharmaceutica Sinica. B2022

Apolipoprotein E and Alzheimer's disease.

Benjamin R Troutwine, Laylan Hamid, Colton R Lysaker, Taylor A Strope, Heather M Wilkins

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Brain, behavior, & immunity - health · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. iScience · 2026
    Article
  12. Review
  13. Review
  14. Lithium chloride suppresses ferroptosis of induced pluripotent stem cells with ApoE4/E4 from a sporadic Alzheimer's disease patient.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  15. The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  16. PreoperativeFrontiers in bioinformatics · 2026
    Review
  17. Review
  18. Exploratory associations between APOE-εFrontiers in neurology · 2026
    Article
  19. Review
  20. Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin R TroutwineDepartment of Neurology University of Kansas Medical Center, Kansas City, KS 66160, USA.
Laylan HamidUniversity of Kansas Alzheimer's Disease Center, Kansas City, KS 66160, USA.
Colton R LysakerUniversity of Kansas Alzheimer's Disease Center, Kansas City, KS 66160, USA.
Taylor A StropeUniversity of Kansas Alzheimer's Disease Center, Kansas City, KS 66160, USA.
Heather M WilkinsDepartment of Neurology University of Kansas Medical Center, Kansas City, KS 66160, USA.
University of Kansas · US

Funding

Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Multidisciplinary Research Training Program in Alzheimer's Disease and Related DisordersT32AG078114 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Sandra A Billinger, Eric Dennis Vidoni · 2022 to 2026
$1.2M
NIA NIH HHS T32 AG078114NICHD NIH HHS U54 HD090216
6 · The paper itself

Abstract

Genetic variation in apolipoprotein E (

Indexed as

Alzheimer's diseaseAmyloid betaApolipoprotein EMitochondriaNeuroinflammationTau

Identifiers

PMID35256931
PMCPMC8897057
OpenAlexW3207508863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.