ArticleNature ecology & evolution2022
Experimental manipulation of microbiota reduces host thermal tolerance and fitness under heat stress in a vertebrate ectotherm.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Experimental temperatures shape host microbiome diversity and composition.Global change biology · 2023Pooled it
- Timescale mismatch: redefining ecological opportunity for evolution in the Anthropocene.The EMBO journal · 2026Article
- Exposure to Environmental Microbes Alters Responsiveness of Tadpole Gut Microbiome to Dietary Tannins.Integrative zoology · 2026Article
- Gut yeasts accelerate chill coma recovery in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Integrated Gut-Brain Axis Response to Freezing and Recovery in Freeze-Tolerant Fish,Animals : an open access journal from MDPI · 2026Article
- Phylosymbiosis and functional redundancy in the Drosophila (Diptera: Drosophilidae) gut microbiome and its implications for host fitness.Journal of insect science (Online) · 2026Article
- Beyond the core microbiome: endemic bacteria drive functional and microdiversity differences across salamander populations.ISME communications · 2026Article
- Effects of naturalistic housing conditions on amphibian growth and microbiome in captivity.Animal microbiome · 2025Article
- AmphiTherm: a comprehensive database of amphibian thermal tolerance and preference.Scientific data · 2025Article
- Host-Microbiome Interactions as Moderators of Host Quality and Biodiversity-Disease Relationships.Integrative and comparative biology · 2025Review
- Article
- Gut microbial contributions to thermogenesis.The Journal of experimental biology · 2025Review
- Exposure to Rice Straw Ash Alters Survival, Development and Microbial Diversity in Amphibian Tadpoles.Ecology and evolution · 2025Article
- The gut-liver axis plays a limited role in mediating the liver's heat susceptibility of Chinese giant salamander.BMC genomics · 2025Article
- Gut microbiomes are largely unchanged when exposed to their amphibian host's latitudinally variable upper thermal limit.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Biodiversity within phytoplankton-associated microbiomes regulates host physiology, host community ecology, and nutrient cycling.mSystems · 2025Article
- Reciprocal translocation experiments reveal gut microbiome plasticity and host specificity in a Qinghai-Xizang Plateau lizard.Zoological research · 2025Article
- Modeling the zebrafish gut microbiome's resistance and sensitivity to climate change and parasite infection.Frontiers in microbiomes · 2025Article
- Diets shape thermal responses in Chinese giant salamanders by altering liver metabolism.Frontiers in microbiology · 2025Article
- Associations Between Gut Microbiota Diversity and a Host Fitness Proxy in a Naturalistic Experiment Using Threespine Stickleback Fish.Molecular ecology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Identifying factors that influence how ectothermic animals respond physiologically to changing temperatures is of high importance given current threats of global climate change. Host-associated microbial communities impact animal physiology and have been shown to influence host thermal tolerance in invertebrate systems. However, the role of commensal microbiota in the thermal tolerance of ectothermic vertebrates is unknown. Here we show that experimentally manipulating the tadpole microbiome through environmental water sterilization reduces the host's acute thermal tolerance to both heat and cold, alters the thermal sensitivity of locomotor performance, and reduces animal survival under prolonged heat stress. We show that these tadpoles have reduced activities of mitochondrial enzymes and altered metabolic rates compared with tadpoles colonized with unmanipulated microbiota, which could underlie differences in thermal phenotypes. These results demonstrate a strong link between the microbiota of an ectothermic vertebrate and the host's thermal tolerance, performance and fitness. It may therefore be important to consider host-associated microbial communities when predicting species' responses to climate change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.