ArticleHypertension research : official journal of the Japanese Society of Hypertension2022
Effects of renin-angiotensin system inhibitors on the incidence of unplanned dialysis.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Discontinuation versus continuation of renin-angiotensin system inhibitors in chronic kidney disease stage 3-5 patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Pre-Dialysis Trajectory of Brain Natriuretic Peptide Levels and Body Weight in Chronic Kidney Disease Patients: A Predictive Marker for Unplanned Dialysis Initiation.Kidney medicine · 2026Article
- Generalised Bullous Pemphigoid in a Young Man After Exposure to Haemodialysis Membrane: A Case Report.Indian dermatology online journal · 2025Article
- Cardiometabolic Dysregulation and Heart Failure.Reviews in cardiovascular medicine · 2025Review
- Advances and challenges in kidney fibrosis therapeutics.Nature reviews. Nephrology · 2025Review
- An updated systematic review of the risk factors for unplanned dialysis initiation.Clinical kidney journal · 2024Review
- Association between stopping renin-angiotensin system inhibitors immediately before hemodialysis initiation and subsequent cardiovascular events.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- 2023 update and perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Need to continue or discontinue RAS inhibitors as CKD stage advances? Any alternative?Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Review
- Role of renin-angiotensin system blockade in advanced CKD: to use or not to use?Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unplanned dialysis initiation is associated with poor outcomes. It is controversial whether patients with advanced chronic kidney disease (CKD) should receive renin-angiotensin system (RAS) inhibitor therapy. The aim of this study was to evaluate the effect of RAS inhibitor therapy in patients with advanced CKD on the incidence of unplanned dialysis initiation. This single-center, retrospective study included patients who started maintenance dialysis at our hospital between April 2014 and March 2021. Patients who initiated dialysis within 6 months of nephrology referral or after kidney transplant were excluded. Among 334 patients (aged 70.0 [59.0-79.0] years; 28.4% women), 186 (55.7%) and 148 (44.3%) had planned and unplanned dialysis initiation, respectively. Multivariate logistic regression analysis revealed that the use of RAS inhibitors was significantly associated with a lower incidence of unplanned dialysis initiation (odds ratio [OR], 0.36; P < 0.01). Female sex (OR, 0.41; P < 0.05), use of potassium binders (OR, 0.28; P < 0.001), earlier referral to nephrology (OR, 0.39; P < 0.01), and earlier discussion of renal replacement therapy (OR, 0.33; P < 0.001) were also significantly associated with a lower incidence, whereas older age (OR, 1.28; P < 0.05), higher Charlson Comorbidity Index (OR, 1.24; P < 0.05), and faster decline in kidney function (OR, 1.29; P < 0.01) were associated with a higher risk of unplanned dialysis initiation. RAS inhibitor therapy in patients with advanced CKD is associated with a lower risk of unplanned dialysis initiation.
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