ArticleNature biomedical engineering2022
In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Photonics Breakthroughs 2025: Mask-Based Integrated Miniscope for Large-scale Volumetric Imaging.IEEE photonics journal · 2026Article
- Compact on-chip fluorescence microscope for dynamic imaging of cellular processes and biomimetic systems.JPhys photonics · 2026Article
- Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Biologically inspired microlens array camera for high-resolution wide field-of-view imaging.Nature communications · 2026Article
- Versatile optical frontends for multicolor fluorescence imaging with miniaturized lensless sensors.Biomedical optics express · 2026Article
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- An optical meta-image-processor for enhanced imaging through strongly scattering media.Nature communications · 2025Article
- Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM).Science advances · 2025Article
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- DeepInMiniscope: Deep learning-powered physics-informed integrated miniscope.Science advances · 2025Article
- Maskless and on-chip LED-array microscope with spatially-varying angle calibration for centimeter-scale phase imaging.bioRxiv : the preprint server for biology · 2025Article
- Wide-field, high-resolution reconstruction in computational multi-aperture miniscope using a Fourier neural network.Optica · 2024Article
- Direct laser writing-enabled 3D printing strategies for microfluidic applications.Lab on a chip · 2024Review
- DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology.Nature communications · 2024Article
- Virus detection light diffraction fingerprints for biological applications.Science advances · 2024Article
- Multicolor fluorescence microscopy for surgical guidance using a chip-scale imager with a low-NA fiber optic plate and a multi-bandpass interference filter.Biomedical optics express · 2024Article
- Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.Nature communications · 2024Article
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- Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor.Scientific reports · 2023Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The simple and compact optics of lensless microscopes and the associated computational algorithms allow for large fields of view and the refocusing of the captured images. However, existing lensless techniques cannot accurately reconstruct the typical low-contrast images of optically dense biological tissue. Here we show that lensless imaging of tissue in vivo can be achieved via an optical phase mask designed to create a point spread function consisting of high-contrast contours with a broad spectrum of spatial frequencies. We built a prototype lensless microscope incorporating the 'contour' phase mask and used it to image calcium dynamics in the cortex of live mice (over a field of view of about 16 mm
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