ArticleSchizophrenia (Heidelberg, Germany)2022
Causal connectivity from right DLPFC to IPL in schizophrenia patients: a pilot study.
Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Potential Targets for Scalp Acupuncture and Brain Stimulation in Mental Disorders: Evidence From Large-Scale Meta-Analyses.Alpha psychiatry · 2026Pooled it
- Efficacy of transcranial magnetic stimulation in anorexia nervosa: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2025Pooled it
- Effects of repetitive transcranial magnetic stimulation of the right inferior parietal lobe on the body image perception in anorexia nervosa: A pilot randomized controlled study.Brain and behavior · 2024Trial
- Diverse and distributed haemodynamic effects of theta burst stimulation in the prefrontal cortex.Neuroimage. Reports · 2025Article
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) in Monitoring Treatment Response in Psychiatry: A Scoping Review.Journal of clinical medicine · 2025Review
- Disparities in accelerated brain aging in recent-onset and chronic schizophrenia.Psychological medicine · 2025Article
- Combining transcranial magnetic stimulation with training to improve social cognition impairment in schizophrenia: a pilot randomized controlled trial.Frontiers in psychology · 2024Article
- Impacts of complex electromagnetic radiation and low-frequency noise exposure conditions on the cognitive function of operators.Frontiers in public health · 2023Article
- Impacts of repetitive transcranial magnetic stimulation parameters on cerebral hemodynamics in patients with disorders of consciousness.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Abnormal function and connectivity of the fronto-parietal network (FPN) have been documented in patients with schizophrenia, but studies are correlational. We applied repetitive transcranial magnetic stimulation (rTMS) to the dorso-lateral prefrontal cortex (DLPFC) and observed causal connectivity to the inferior parietal lobe (IPL). We hypothesized that patients with schizophrenia would have lower activation and slower reaction in the IPL following DLPFC stimulation. Thirteen patients with schizophrenia (SZ) and fourteen healthy controls subjects (HC) underwent rTMS at 10 Hz to the right DLPFC. Simultaneously, we measured brain activation in the IPL, represented as oxygenized hemoglobin (HbO) levels, using functional near-infrared spectroscopy (fNIRS). rTMS consisted of 20 trains of impulses at 10 Hz for 3 seconds, and 60 seconds waiting time. Using NIRSLab software, GLM was applied to estimate both hemodynamic response function (HRF) and its derivative. Following TMS to the DLPFC, SZ showed a smaller decrease in HbO levels in the bilateral IPL than HC (p = 0.05). Timecourse analysis revealed an immediate decrease in parietal HbO levels in HC, but not in SZ. This difference was significant (at a threshold level of p ≤ 0.05, with Bonferroni correction) for several time segments and channels in both rights and left IPL. Our findings suggest abnormal fronto-temporal connectivity in patients with schizophrenia, beyond a mere decrease or slowing of information processing. This is in line with the hypothesis of reduced fronto-parietal inhibition in schizophrenia.
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