Evidence map›Paper›PMID 35256530›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency.

Yihui Zhang, Dainan Li, Youad Darwish, Xin Fu, Laurence O Trussell, Hai Huang

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Direct cellular contact byScience advances · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Cannabidiol Modulates M-Type KBiomedicines · 2023
    Article
  10. Regulation of Neurotransmitter Release by KAdvances in neurobiology · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yihui ZhangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Dainan LiDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Youad DarwishDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Xin FuBrain Institute, Tulane University, New Orleans, LA 70118.
Laurence O TrussellOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0003-1171-2356
Hai HuangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 hhuang5@tulane.edu.ORCID 0000-0002-6928-3198
Tulane University · USOregon Health & Science University · US

Funding

Synaptic mechanisms in the auditory system (Administrative Supplement)R01DC004450 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 1999 to 2026
$10.6M
Regulation of axonal and synaptic signaling in interneuron (supplement)R35NS116798 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 2020 to 2026
$4.1M
Synaptic mechanisms of auditory information processingR01DC016324 · NIDCD · TULANE UNIVERSITY OF LOUISIANA · PI Hai Huang · 2018 to 2026
$2.5M
Ion channels and presynaptic function of an auditory synapseR00DC012063 · NIDCD · TULANE UNIVERSITY OF LOUISIANA · PI HUANG, HAI · 2014 to 2016
$745k
Ion channels and presynaptic function of an auditory synapseK99DC012063 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI HUANG, HAI · 2012 to 2013
$177k
NIDCD NIH HHS K99 DC012063NIDCD NIH HHS R00 DC012063NIDCD NIH HHS R01 DC004450NIDCD NIH HHS R01 DC016324NINDS NIH HHS R35 NS116798
6 · The paper itself

Abstract

The presynaptic action potential (AP) is required to drive calcium influx into nerve terminals, resulting in neurotransmitter release. Accordingly, the AP waveform is crucial in determining the timing and strength of synaptic transmission. The calyx of Held nerve terminals of rats of either sex showed minimum changes in AP waveform during high-frequency AP firing. We found that the stability of the calyceal AP waveform requires KCNQ (K

Indexed as

CalciumSynaptic TransmissionAction PotentialsAnimalsNeurotransmitter AgentsPresynaptic TerminalsRatsSodiumCalciumNeurotransmitter AgentsSodiumaction potential waveformaxon terminalcalyx of Heldchannel inactivationKCNQ channelssynaptic transmission

Identifiers

PMID35256530
PMCPMC9034779
OpenAlexW4220826156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.