Evidence map›Paper›PMID 35256511›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Sex Influences Age-Related Changes in Natural Antibodies and CD5

Sarah E Webster, Brinda Ryali, Michael J Clemente, Naomi L Tsuji, Nichol E Holodick

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. B1 Cells for Life.Immunological reviews · 2026
    Review
  4. Article
  5. The transcription factor Bcl11a is essential for B-1a cell maintenance during aging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah E WebsterCenter for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI.ORCID 0000-0003-0884-9458
Brinda RyaliCenter for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI.
Michael J ClementeCenter for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI.ORCID 0000-0003-4345-3934
Naomi L TsujiCenter for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI.ORCID 0000-0003-0358-848X
Nichol E HolodickCenter for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI; nichol.holodick@med.wmich.edu.ORCID 0000-0002-2671-6918
Western Michigan University · USRush University Medical Center · US

Funding

Sex Determines Age-related Changes in the Repertoire and Function of Natural Antibodies Protective against Streptococcus pneumoniae with Increasing AgeR01AI154539 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI HOLODICK, NICHOL ELIZABETH · 2020 to 2023
$1.5M
NIAID NIH HHS R01 AI154539
6 · The paper itself

Abstract

Natural Abs are primarily produced by B-1 cells and are essential for protection against

Indexed as

B-Lymphocyte SubsetsPneumococcal InfectionsAnimalsAntibodies, BacterialCD5 AntigensFemaleImmunoglobulin MMaleMiceStreptococcus pneumoniaeAntibodies, BacterialCD5 AntigensImmunoglobulin M

Identifiers

PMID35256511
PMCPMC8976758
OpenAlexW4221130065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.