Evidence map›Paper›PMID 35256489›Full record

Trial reportSaudi medical journal2022

The effect of low flow anesthesia with sevoflurane on oxidative status: A prospective, randomized study.

Hülya Kaşıkara, Ayça T Dumanlı Özcan, Cemile K Biçer, Almila Şenat, Abdüssamet Yalçın, Cemile Altın, Şemsi Mustafa Aksoy, Abdülkadir But

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06611449 (The Effect of Minimal Flow Anesthesia on Oxidative and Neuroendocrine Stress Response), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06611449 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of Minimal Flow Anesthesia on Oxidative and Neuroendocrine Stress Response

TypeinterventionalSponsorBezmialem Vakif UniversityRan2024 to 2024Enrolled2ConditionsLow Flow Anesthesia, Oxidative Stress, Neuroinflammatory ResponseArmsThe minimal flow anesthesia with sevoflurane group, The high flow anesthesia with sevoflurane group
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hülya KaşıkaraFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Ayça T Dumanlı ÖzcanFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Cemile K BiçerFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Almila ŞenatFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Abdüssamet YalçınFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Cemile AltınFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Şemsi Mustafa AksoyFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
Abdülkadir ButFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery.

methodsThe study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min

resultsDisulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values.

conclusionIt was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.

Indexed as

AnesthesiaDisulfidesHumansOxidative StressProspective StudiesSevofluraneDisulfidesSevofluranelow-flow anesthesiaoxidative statussevofluranethiol/disulfide homeostasis

Identifiers

PMID35256489
PMCPMC9280541

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.