Evidence map›Paper›PMID 35256487›Full record

ArticleJournal of medical ethics2022

The unnaturalistic fallacy: COVID-19 vaccine mandates should not discriminate against natural immunity.

Jonathan Pugh, Julian Savulescu, Rebecca C H Brown, Dominic Wilkinson

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Scope and Spatio-Temporal Patterns of Workplace Vaccination Mandates During the COVID-19 Pandemic.International journal of environmental research and public health · 2025
    Article
  3. A Global Index to Quantify Discrimination Resulting from COVID-19 Pandemic Response Policies.International journal of environmental research and public health · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. COVID-19 Vaccines and the Virtues.Public health ethics · 2022
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Jonathan PughThe Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK jonathan.pugh@philosophy.ox.ac.uk.
Julian SavulescuThe Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK.ORCID 0000-0003-1691-6403
Rebecca C H BrownThe Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK.ORCID 0000-0001-8023-1092
Dominic WilkinsonThe Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK.ORCID 0000-0003-3958-8633
University of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

COVID-19 vaccine requirements have generated significant debate. Here, we argue that, on the evidence available, such policies should have recognised proof of natural immunity as a sufficient basis for exemption to vaccination requirements. We begin by distinguishing our argument from two implausible claims about natural immunity: (1) natural immunity is superior to 'artificial' vaccine-induced immunity simply because it is 'natural' and (2) it is better to acquire immunity through natural infection than via vaccination. We then briefly survey the evidence base for the comparison between naturally acquired immunity and vaccine-induced immunity. While we clearly cannot settle the scientific debates on this point, we suggest that we lack clear and convincing scientific evidence that vaccine-induced immunity has a significantly higher protective effect than natural immunity. Since vaccine requirements represent a substantial infringement of individual liberty, as well as imposing other significant costs, they can only be justified if they are necessary for achieving a proportionate public health benefit. Without compelling evidence for the superiority of vaccine-induced immunity, it cannot be deemed necessary to require vaccination for those with natural immunity. Subjecting them to vaccine mandates is therefore not justified. We conclude by defending the standard of proof that this argument from necessity invokes, and address other pragmatic and practical considerations that may speak against natural immunity exemptions.

Indexed as

COVID-19VaccinesCOVID-19 VaccinesHumansImmunity, InnateVaccinationCOVID-19 VaccinesVaccinesCOVID-19ethicspublic policy

Identifiers

PMID35256487
PMCPMC9132858
OpenAlexW4220934024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.