Evidence map›Paper›PMID 35256485›Full record

ArticleNeurology2022

Role of NODDI in the MRI Characterization of Hippocampal Abnormalities in Temporal Lobe Epilepsy: Clinico-histopathologic Correlations.

Isabella Giachetti, Francesco Padelli, Domenico Aquino, Rita Garbelli, Dalia De Santis, Laura Rossini, Francesco Deleo, Riccardo Pascuzzo, Roland Coras, Gianluca Marucci and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Isabella GiachettiFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-9944-268X
Francesco PadelliFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-0390-7789
Domenico AquinoFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-1289-9573
Rita GarbelliFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-6475-4974
Dalia De SantisFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-2519-2067
Laura RossiniFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.
Francesco DeleoFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0003-0808-3042
Riccardo PascuzzoFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0001-6555-1784
Roland CorasFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0001-8617-0913
Gianluca MarucciFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0003-4508-3359
Giovanni TringaliFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.
Carmelo MaccagnanoFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.
Marco De CurtisFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.
Maria Grazia BruzzoneFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.
Giuseppe DidatoFrom the Neuroradiology Unit (I.G., F.P., D.A., R.P., C.M., M.G.B.), Scientific Department (F.P.), Epilepsy Unit (R.G., D.D.S., L.R., F.D., M.D.C., G.D.), Neuropathology Unit (G.M.), and Neurosurgery Unit (G.T.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; and Department of Neuropathology (R.C.), University Hospital Erlangen, Germany.ORCID 0000-0002-4812-6310
Fondazione IRCCS Istituto Neurologico Carlo Besta · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe identification of possible hippocampal alterations is a crucial point for the diagnosis and therapy of patients with unilateral temporal lobe epilepsy (TLE). This study aims to investigate the role of neurite orientation dispersion and density imaging (NODDI) compared to diffusion tensor imaging (DTI) in the comprehension of hippocampal microstructure in TLE.

methodsDTI and NODDI metrics were calculated in the hippocampi of adult patients with TLE, with and without histology-confirmed hippocampal sclerosis (HS), and in age/sex-matched healthy controls (HC). Diffusion metrics and hippocampal volumes of the pathologic side were compared within participants and between participants among the HS, non-HS, and HC groups. Diffusion metrics were also correlated with hippocampal volume and patients' clinical features. After surgery, hippocampal specimens were processed for neuropathology examinations.

resultsFifteen patients with TLE (9 with and 6 without HS) and 11 HC were included. Hippocampal analyses resulted in a significant increase in fractional anisotropy (FA) and mean diffusivity (MD; mm DISCUSSION: This study shows the capability of diffusion MRI metrics to detect hippocampal microstructural alterations. Among them, ODI seems to better highlight the fiber reorganization observed by neuropathology in sclerotic hippocampi.

Indexed as

Epilepsy, Temporal LobeAdultAtrophyDiffusion Tensor ImagingHippocampusHumansMagnetic Resonance ImagingNeuritesSclerosis

Identifiers

PMID35256485
PMCPMC9071371
OpenAlexW4220667761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.