ArticleeLife2022
Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit.
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In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2026Pooled it
- Comprehensive evaluation of the efficacy and safety of different vitamin D combination regimens based on indirect comparisons for children with rickets: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2025Pooled it
- Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.Nutrients · 2024Trial
- Does maternal vitamin D status influence placental weight or vascular and inflammatory pathology? Secondary analysis from the Kellogg Pregnancy Study.The Journal of steroid biochemistry and molecular biology · 2023Trial
- Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.Journal of public health (Oxford, England) · 2023Trial
- Prenatal high-dose vitamin D supplementation and offspring bone mineral content and density at age 13 years: a secondary analysis of a randomised clinical trial.The Lancet regional health. Europe · 2026Article
- Article
- Vitamin D as a cellular endocrine system: Tissue-specific microcircuits, immune reprogramming, and metabolic resistance.iScience · 2026Review
- Maternal-neonatal vitamin D gradient at birth in Ilorin, Nigeria: a comparative cross-sectional study.Maternal health, neonatology and perinatology · 2026Article
- Integrative analysis of placental metabolic reprogramming and microbiome alterations in gestational diabetes mellitus (GDM).Acta diabetologica · 2026Review
- The Double-Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Review
- 25-Hydroxyvitamin DCommunications medicine · 2026Article
- The Protective Effect of Vitamin D Against Necroptosis in Preeclampsia.Journal of pregnancy · 2026Article
- A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Molecular features of AHDC1: insights into an overlooked gene with broad functional potential.Human genetics · 2025Review
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 5 countries.
Brogan Ashley *The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.
Claire Simner *The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.
Antigoni ManousopoulouBeckman Research Institute, City of Hope National Medical Center, Duarte, United States.
Carl JenkinsonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-1838-5282
Felicity HeyNIHR Cambridge Biomedical Research Centre, Nutritional Biomarker Laboratory. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Clifford Allbutt Building, Cambridge Biomedical Campus, Cambridge, United Kingdom.ORCID 0000-0003-2695-4817
Jennifer M FrostCentre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.ORCID 0000-0002-3057-6313
Faisal I RezwanThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-9921-222X
Cory H WhiteThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-1619-0174
Emma M LofthouseThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-0175-5590
Emily HydeThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-5084-3709
Laura D F CookeThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-8099-9437
Sheila BartonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-4963-4242
Pamela MahonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-0661-572X
Elizabeth M CurtisMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-5147-0550
Rebecca J MoonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-2334-2284
Sarah R CrozierMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-9524-1127
Hazel M InskipMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-8897-1749
Keith M GodfreyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-4643-0618
John W HollowayThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-9998-0464
Cyrus CooperMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-3510-0709
Kerry S JonesNIHR Cambridge Biomedical Research Centre, Nutritional Biomarker Laboratory. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Clifford Allbutt Building, Cambridge Biomedical Campus, Cambridge, United Kingdom.ORCID 0000-0002-7380-9797
Rohan M LewisThe Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-4044-9104
Martin HewisonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-5806-9690
Spiros D D GarbisProteas Bioanalytics Inc, BioLabs at the Lundquist Institute, Torrance, United States.ORCID 0000-0002-1050-0805
Miguel R BrancoCentre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.ORCID 0000-0001-9447-1548
Nicholas C Harvey *MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-8194-2512
Jane K Cleal *The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-7978-4327
University of Southampton · GBMRC Lifecourse Epidemiology Unit · GBUniversity Hospital Southampton NHS Foundation Trust · GBMerck (Germany) · DEQueen Mary University of London · GBUniversity of Birmingham · GBCity Of Hope National Medical Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US
Funding
Interdisciplinary Research Network on Early Adversity & Later Life ReversibilityU24AG047867 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GODFREY, KEITH, MCEWEN, BRUCE S. · 2014 to 2018
$954kUse of Protein Biomarkers to Identify Latent/Persistent HIV Infected Cell Reservoirs Without Induced ReactivationR21AI122389 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SPINA, CELSA A · 2016 to 2017
$365kBiotechnology and Biological Sciences Research Council BB/P028179/1British Heart Foundation RG/15/17/3174Department of Health 17/63/154Department of Health IS-BRC-1215-20004Department of Health ISBRC-1215-20014Department of Health NF-SI-0515-10042Medical Research Council 4050502589Medical Research Council G0400491Medical Research Council G0601019Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MC_UU_12011/4Medical Research Council U105960371NIAID NIH HHS R21 AI122389NIA NIH HHS U24 AG047867Versus Arthritis 21231Wellcome TrustWellcome Trust 201268/Z/16/Z
Abstract
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships between maternal 25(OH)D and fetal physiology. We demonstrate active placental uptake of 25(OH)D
Indexed as
PlacentaVitamin DCalcifediolFemaleFetusHumansPregnancyVitaminsCalcifediolVitamin DVitaminsdevelopmental biologyepigeneticsfetal programminghumanplacentatranscriptomicsVitamin D
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.