Evidence map›Paper›PMID 35256032›Full record

ArticlePsychological medicine2023

Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.

Mikaela K Dimick, Megan A Hird, Alysha A Sultan, Rachel H B Mitchell, Mark Sinyor, Bradley J MacIntosh, Benjamin I Goldstein

Open access · hybridAbstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mikaela K DimickCentre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-8371-1585
Megan A HirdMD Program, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Alysha A SultanCentre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Rachel H B MitchellDepartment of Psychiatry, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Mark SinyorDepartment of Psychiatry, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Bradley J MacIntoshHurvitz Brain Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Benjamin I GoldsteinCentre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Sunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuicide is the second leading cause of death in all youth and among adults with bipolar disorder (BD). The risk of suicide in BD is among the highest of all psychiatric conditions. Self-harm, including suicide attempts and non-suicidal self-injury, is a leading risk factor for suicide. Neuroimaging studies suggest reward circuits are implicated in both BD and self-harm; however, studies have yet to examine self-harm related resting-state functional connectivity (rsFC) phenotypes within adolescent BD.

methodsResting-state fMRI data were analyzed for 141 adolescents, ages 13-20 years, including 38 with BD and lifetime self-harm (BD

resultsBD

conclusionsThis study provides preliminary evidence of altered reward-related rsFC in relation to self-harm in adolescents with BD. Between-group differences conveyed a combination of putative risk and resilience connectivity patterns. Future studies are warranted to evaluate changes in rsFC in response to treatment and related changes in self-harm.

Indexed as

Bipolar DisorderAmygdalaDorsolateral Prefrontal CortexHumansMagnetic Resonance ImagingPrefrontal CortexSuicide, Attemptedadolescencebipolar disorderfunctional MRIself-harm

Identifiers

PMID35256032
PMCPMC10277718
OpenAlexW4220814539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.