Evidence map›Paper›PMID 35255690›Full record

ArticleBiochemistry2022

Control of Unsaturation in

Thomas G Bartholow, Terra Sztain, Megan A Young, D John Lee, Tony D Davis, Ruben Abagyan, Michael D Burkart

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas G BartholowDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Terra SztainDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-1327-8541
Megan A YoungDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-3330-3580
D John LeeDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Tony D DavisDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Ruben AbagyanSchool of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-9309-2976
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4472-2254
University of California San Diego · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
Addressing biomedical challenges with computational mechanics and big dataR35GM131881 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ABAGYAN, RUBEN · 2019 to 2023
$1.9M
Chemistry-Biology Interfaces at UCSDT32GM146648 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael D. Burkart, Alexis C. Komor · 2022 to 2026
$876k
Interrogation of Microbial Natural Product MethyltransferasesR00GM129454 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI DAVIS, TONY D. · 2021 to 2023
$747k
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
Interrogation of Microbial Natural Product MethyltransferasesK99GM129454 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVIS, TONY D. · 2019 to 2019
$93k
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS K99 GM129454NIGMS NIH HHS R00 GM129454NIGMS NIH HHS R01 GM095970NIGMS NIH HHS R35 GM131881NIGMS NIH HHS T32 GM112584NIGMS NIH HHS T32 GM146648
6 · The paper itself

Abstract

Carrier protein-dependent biosynthesis provides a thiotemplated format for the production of natural products. Within these pathways, many reactions display exquisite substrate selectivity, a regulatory framework proposed to be controlled by protein-protein interactions (PPIs). In

Indexed as

Acyl Carrier ProteinFatty AcidsFatty Acid Synthase, Type IIHydro-LyasesEscherichia coliFatty Acids, Unsaturated3-hydroxyacyl-(acyl-carrier-protein) dehydrataseAcyl Carrier ProteinFatty AcidsFatty Acids, UnsaturatedFatty Acid Synthase, Type IIHydro-Lyases

Identifiers

PMID35255690
PMCPMC9769579
OpenAlexW4220916695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.